Discoidin domain
Encyclopedia
Discoidin domain is major domain of many blood coagulation factors.
Blood coagulation factors V
and VIII
contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to C2 domain
). In the Dictyostelium discoideum
(Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. Similar domains have been detected in other extracellular and membrane proteins. In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to anionic phospholipids on the surface of platelets and endothelial cells. The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity. It forms an amphipathic alpha-helix, which binds to the membrane. FA58C contains two conserved cysteines in most proteins, which link the extremities of the domain by a disulfide bond. A further disulfide bond is located near the C-terminal of the second FA58C domain in MFGM .
; CASPR4; CNTNAP1; CNTNAP2
; CNTNAP3; CNTNAP4
; CNTNAP5; CPXM1
; CPXM2; DCBLD1; DCBLD2
; DDR1
; DDR2
; EDIL3;
F5
; F8
; F8B; MFGE8
; NRP1; NRP2
; RS1; SSPO
;
Blood coagulation factors V
Factor V
Factor V is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor...
and VIII
Factor V
Factor V is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor...
contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to C2 domain
C2 domain
A C2 domain is a protein structural domain involved in targeting proteins to cell membranes. It is a beta-sandwich composed of 8 β-strands that co-ordinates two or three calcium ions, which bind in a cavity formed by the first and final loops of the domain, on the membrane binding face.-Coupling...
). In the Dictyostelium discoideum
Dictyostelium discoideum
Dictyostelium discoideum is a species of soil-living amoeba belonging to the phylum Mycetozoa. D. discoideum, commonly referred to as slime mold, is a eukaryote that transitions from a collection of unicellular amoebae into a multicellular slug and then into a fruiting body within its lifetime. D...
(Slime mold) cell adhesion protein discoidin, a related domain, named discoidin I-like domain, DLD, or DS, has been found which shares a common C-terminal region of about 110 amino acids with the FA58C domain, but whose N-terminal 40 amino acids are much less conserved. Similar domains have been detected in other extracellular and membrane proteins. In coagulation factors V and VIII the repeated domains compose part of a larger functional domain which promotes binding to anionic phospholipids on the surface of platelets and endothelial cells. The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity. It forms an amphipathic alpha-helix, which binds to the membrane. FA58C contains two conserved cysteines in most proteins, which link the extremities of the domain by a disulfide bond. A further disulfide bond is located near the C-terminal of the second FA58C domain in MFGM .
Human proteins containing this domain
AEBP1; BTBD9BTBD9
BTBD9 is a human gene.There is some evidence that it may be associated with restless legs syndrome....
; CASPR4; CNTNAP1; CNTNAP2
CNTNAP2
Contactin-associated protein-like 2 is a protein that in humans is encoded by the CNTNAP2 gene.This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal...
; CNTNAP3; CNTNAP4
CNTNAP4
Contactin-associated protein-like 4 is a protein that in humans is encoded by the CNTNAP4 gene.-Further reading:...
; CNTNAP5; CPXM1
CPXM1
Probable carboxypeptidase X1 is an enzyme that in humans is encoded by the CPXM1 gene.-Further reading:...
; CPXM2; DCBLD1; DCBLD2
DCBLD2
Discoidin, CUB and LCCL domain-containing protein 2 is a protein that in humans is encoded by the DCBLD2 gene.-Further reading:...
; DDR1
DDR1
For the older type of computer memory, see DDR SDRAM.Discoidin domain receptor family, member 1, also known as DDR1 or CD167a , is a human gene.-Further reading:...
; DDR2
DDR2 (gene)
Discoidin domain receptor family, member 2, also known as DDR2 or CD167b , is a human gene.-Interactions:DDR2 has been shown to interact with SHC1.-Further reading:...
; EDIL3;
F5
Factor V
Factor V is a protein of the coagulation system, rarely referred to as proaccelerin or labile factor. In contrast to most other coagulation factors, it is not enzymatically active but functions as a cofactor...
; F8
Factor VIII
Factor VIII is an essential blood clotting factor also known as anti-hemophilic factor . In humans, Factor VIII is encoded by the F8 gene...
; F8B; MFGE8
MFGE8
Milk fat globule-EGF factor 8 protein Mfge8), also known as lactadherin, is a protein which in humans is encoded by the MFGE8 gene.- Species distribution :Mfge8 is secreted protein found in vertebrates, including mammals as well as birds....
; NRP1; NRP2
NRP2
Neuropilin-2 is a protein that in humans is encoded by the NRP2 gene.-Further reading:...
; RS1; SSPO
SSPO
SCO-spondin is a protein that in humans is encoded by the SSPO gene.-Further reading:...
;