Dimethocaine
Encyclopedia
Dimethocaine, also known as larocaine, is a local anesthetic
with stimulant
properties that some studies have shown to be half the potency of cocaine
. Anecdotal user reports indicate little euphoria and only mild stimulating effects, with many users failing to perceive any recreational effects whatsoever. The drug however still presents strain on the cardiovascular systems, like cocaine, with the potential to induce tachycardia
which could be problematic for those who continuously redose. Additional reports of respiratory arrest have been noted.
When a product sold online in the UK in June 2010, advertised as dimethocaine was tested, it was found to in fact be a mixture of caffeine
and lidocaine
, and the lack of any dopaminergic stimulant ingredient in such mixes may explain the limited recreational effects reported by many users. Other samples tested have however been shown to contain genuine dimethocaine, and one branded "bath salt" product containing primarily dimethocaine as the active ingredient, was noted to have been particularly subject to abuse by intravenous drug users in Ireland.
The p-NH2 pharmacophore in dimethocaine is a relatively uncommon structural feature for a dopamine reuptake inhibitor
, although it is also present in other compounds such as GYKI-52895
and RTI-29.
Local anesthetic
A local anesthetic is a drug that causes reversible local anesthesia, generally for the aim of having local analgesic effect, that is, inducing absence of pain sensation, although other local senses are often affected as well...
with stimulant
Stimulant
Stimulants are psychoactive drugs which induce temporary improvements in either mental or physical function or both. Examples of these kinds of effects may include enhanced alertness, wakefulness, and locomotion, among others...
properties that some studies have shown to be half the potency of cocaine
Cocaine
Cocaine is a crystalline tropane alkaloid that is obtained from the leaves of the coca plant. The name comes from "coca" in addition to the alkaloid suffix -ine, forming cocaine. It is a stimulant of the central nervous system, an appetite suppressant, and a topical anesthetic...
. Anecdotal user reports indicate little euphoria and only mild stimulating effects, with many users failing to perceive any recreational effects whatsoever. The drug however still presents strain on the cardiovascular systems, like cocaine, with the potential to induce tachycardia
Tachycardia
Tachycardia comes from the Greek words tachys and kardia . Tachycardia typically refers to a heart rate that exceeds the normal range for a resting heart rate...
which could be problematic for those who continuously redose. Additional reports of respiratory arrest have been noted.
When a product sold online in the UK in June 2010, advertised as dimethocaine was tested, it was found to in fact be a mixture of caffeine
Caffeine
Caffeine is a bitter, white crystalline xanthine alkaloid that acts as a stimulant drug. Caffeine is found in varying quantities in the seeds, leaves, and fruit of some plants, where it acts as a natural pesticide that paralyzes and kills certain insects feeding on the plants...
and lidocaine
Lidocaine
Lidocaine , Xylocaine, or lignocaine is a common local anesthetic and antiarrhythmic drug. Lidocaine is used topically to relieve itching, burning and pain from skin inflammations, injected as a dental anesthetic or as a local anesthetic for minor surgery.- History :Lidocaine, the first amino...
, and the lack of any dopaminergic stimulant ingredient in such mixes may explain the limited recreational effects reported by many users. Other samples tested have however been shown to contain genuine dimethocaine, and one branded "bath salt" product containing primarily dimethocaine as the active ingredient, was noted to have been particularly subject to abuse by intravenous drug users in Ireland.
The p-NH2 pharmacophore in dimethocaine is a relatively uncommon structural feature for a dopamine reuptake inhibitor
Dopamine reuptake inhibitor
A dopamine reuptake inhibitor is a type of drug that acts as a reuptake inhibitor for the neurotransmitter dopamine by blocking the action of the dopamine transporter...
, although it is also present in other compounds such as GYKI-52895
GYKI-52895
GYKI-52895 is a drug which is a 2,3-benzodiazepine derivative. Unlike other similar drugs, GYKI-52895 is a selective dopamine reuptake inhibitor, which presumably would produce stimulant effects in vivo....
and RTI-29.