The Diels Reese Reaction was first reported in 1934 by O. Diels and J. Reese. An extension to the reaction was made by William Hearon. The reaction is believe to proceed through an unknown intermediate or adduct as proposed by Hearon. By changing the solvent the resulting product will change. With acetic acid as solvent (acidic pH), the reaction yields the diphenylpyrazolone. With xylene as solvent (neutral pH), the reaction gives the indole, and with pyridine (basic pH), the reaction afforded the carbomethoxyquinoline which can be degraded to the dihydroquinoline.

See Indole

Indole

Indole is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. Indole is a popular component of fragrances and the precursor to many pharmaceuticals. Compounds that contain an...