Desmethoxyyangonin
Encyclopedia
Desmethoxyyangonin or 5,6-dehydrokawain is one of the six major kavalactone
s found in the Piper methysticum (kava) plant.
of monoamine oxidase B
(MAO-B). It is able to increase dopamine
levels in the nucleus accumbens
. This may be the reason for the euphoria
from Kava consumption.
Desmethoxyyangonin has marked activity on the induction of CYP3A23.
Kavalactone
Kavalactones are a class of lactone compounds found in the kava shrub.-Compounds:At least 18 different kavalactones have been identified to date, with methysticin being the first identified.Analogues, such as ethysticin, have also been isolated....
s found in the Piper methysticum (kava) plant.
Pharmacology
Desmethoxyyangonin is a reversible inhibitorMonoamine oxidase inhibitor
Monoamine oxidase inhibitors are a class of antidepressant drugs prescribed for the treatment of depression. They are particularly effective in treating atypical depression....
of monoamine oxidase B
Monoamine oxidase B
Monoamine oxidase B, also known as MAOB, is a protein that in humans is encoded by the MAOB gene.The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is an enzyme located in the mitochondrial outer membrane...
(MAO-B). It is able to increase dopamine
Dopamine
Dopamine is a catecholamine neurotransmitter present in a wide variety of animals, including both vertebrates and invertebrates. In the brain, this substituted phenethylamine functions as a neurotransmitter, activating the five known types of dopamine receptors—D1, D2, D3, D4, and D5—and their...
levels in the nucleus accumbens
Nucleus accumbens
The nucleus accumbens , also known as the accumbens nucleus or as the nucleus accumbens septi , is a collection of neurons and forms the main part of the ventral striatum...
. This may be the reason for the euphoria
Euphoria
Euphoria is an emotional and mental state defined as a sense of great elation and well being.Euphoria may also refer to:* Euphoria , a genus of scarab beetles* Euphoria, a genus name previously used for the longan and other trees...
from Kava consumption.
Desmethoxyyangonin has marked activity on the induction of CYP3A23.