The dermoepidermal junction is the area of tissue that joins the epidermal and the dermal

Dermis

The dermis is a layer of skin between the epidermis and subcutaneous tissues, and is composed of two layers, the papillary and reticular dermis...

 layers of the skin. The basal cells in the stratum basale of the epidermis connect to the basement membrane

Basement membrane

The basement membrane is a thin sheet of fibers that underlies the epithelium, which lines the cavities and surfaces of organs including skin, or the endothelium, which lines the interior surface of blood vessels.- Composition :...

 by hemidesmosomes; the cells of the papillary layer of the dermis are attached to the basement membrane by anchoring fibrils

Anchoring fibrils

Anchoring fibrils extend from the basal lamina of epithelial cells and attach to the lamina reticularis by wrapping around the reticular fiber bundles. The basal lamina and lamina reticularis together make up the basement membrane...

.

Stevens-Johnson syndrome

Stevens-Johnson syndrome

Stevens–Johnson syndrome and toxic epidermal necrolysis are two forms of a life-threatening skin condition, in which cell death causes the epidermis to separate from the dermis. The syndrome is thought to be a hypersensitivity complex that affects the skin and the mucous membranes...

 and toxic epidermal necrolysis

Toxic epidermal necrolysis

Toxic epidermal necrolysis is a rare, life-threatening dermatological condition that is usually induced by a reaction to medications...

are diseases where there is a breakdown of the dermoepidermal junction.