Decerebrate
Encyclopedia
Decerebration is the elimination of cerebral brain function in an animal by removing the cerebrum, cutting across the brain stem
Brain stem
In vertebrate anatomy the brainstem is the posterior part of the brain, adjoining and structurally continuous with the spinal cord. The brain stem provides the main motor and sensory innervation to the face and neck via the cranial nerves...

, or severing certain arteries in the brain stem.

Decerebration describes the ligation along the neural axis in distinct parts of the brain in experimental animals. Generally we distuingish between lower decerebration (the cut is made above the upper border of the pons), middle decerebration (cut is made through the red nucleus) and upper decerebration (cut is made so the cortical area is removed). As a result the animal abolishes certain reflexes which are integrated in different parts of the brain. Furthermore the reflexes which are functional will be hyperreactive (and therefore very accentuated) due to the removal of inhibiting higher brain centers (e.g. the facilitatory area of the reticular formation
Reticular formation
The reticular formation is a part of the brain that is involved in actions such as awaking/sleeping cycle, and filtering incoming stimuli to discriminate irrelevant background stimuli...

 will not receive regulating input from cerebellum
Cerebellum
The cerebellum is a region of the brain that plays an important role in motor control. It may also be involved in some cognitive functions such as attention and language, and in regulating fear and pleasure responses, but its movement-related functions are the most solidly established...

, basal ganglia
Basal ganglia
The basal ganglia are a group of nuclei of varied origin in the brains of vertebrates that act as a cohesive functional unit. They are situated at the base of the forebrain and are strongly connected with the cerebral cortex, thalamus and other brain areas...

 and the cortex
Cerebral cortex
The cerebral cortex is a sheet of neural tissue that is outermost to the cerebrum of the mammalian brain. It plays a key role in memory, attention, perceptual awareness, thought, language, and consciousness. It is constituted of up to six horizontal layers, each of which has a different...

).

Lower decerebration results in a "Bulbospinal" animal:
Reflexes which are integrated within the spinal cord and medulla oblongata are functional, reflexes integrated in midbrain and cortex are absent.
Types of reflexes present in bulbospinal animal
Reflex Stimulus Response Receptor
Stretch reflex Stretch Contraction of muscle Muscle spindles
Positive supporting reaction (magnet reaction) Contact with sole or palm Foot extended to support body Proprioceptors in distal flexors
Negative supporting reaction Stretch Release of positive supporting reaction Proprioceptors in extensors
Tonic labyrinthine reflexes Gravity Contraction of limb extensor muscles Otolithic
Otolith
An otolith, , also called statoconium or otoconium is a structure in the saccule or utricle of the inner ear, specifically in the vestibular labyrinth of vertebrates. The saccule and utricle, in turn, together make the otolith organs. They are sensitive to gravity and linear acceleration...

 organs
Tonic neck reflexes Head turned (1) To side, (2) Up, (3) Down Change in pattern of contraction (1) Extension of limbs on side to which head is turned, (2) Hind flex leg, (3) Foreleg flex Neck proprioceptors


The most obvious accentuation is seen in the tonic labyrinthine reflexes, the otholitic organ mediates input about the gravitational force exerted on the body and the labyrinthine reflex acts on the extensor muscles in order to resist this gravitational force. In an animal where the cortical areas or the midbrain have been "cut off" from the neural axis, this reflex is hyperactive and the animal will maximally extend all four limbs. This phenomenon is known as decerebrate rigidity. In humans true decerebrate rigidty is rare since the damage to the brain centers it might be caused by usually are lethal. However decorticate rigidity can be caused by e.g. bleeding in the internal capsule
Internal capsule
The internal capsule is an area of white matter in the brain that separates the caudate nucleus and the thalamus from the lenticular nucleus. The internal capsule contains both ascending and descending axons....

 which causes damage to upper motor neurons. The symptoms of decorticate rigidity are flexion in the upper limbs and extension in the lower limbs.
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