Alisporivir or Debio 025, DEB025, (or UNIL-025) is a cyclophilin

Cyclophilin

Cyclophilins are a family of proteins from vertebrates and other organisms that bind to cyclosporine, an immunosuppressant which is usually used to suppress rejection after internal organ transplants...

 inhibitor. Its structure is reminiscent of, and synthesized from ciclosporin

Ciclosporin

Ciclosporin , cyclosporine , cyclosporin , or cyclosporin A is an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the immune system, and therefore the risk of organ rejection...

.

It inhibits cyclophilin D. Alisporivir is not immunosuppressive.

It is being researched for potential use in the treatment of hepatitis C

Hepatitis C

Hepatitis C is an infectious disease primarily affecting the liver, caused by the hepatitis C virus . The infection is often asymptomatic, but chronic infection can lead to scarring of the liver and ultimately to cirrhosis, which is generally apparent after many years...

. It has also been investigated for Duchenne muscular dystrophy

Duchenne muscular dystrophy

Duchenne muscular dystrophy is a recessive X-linked form of muscular dystrophy, which results in muscle degeneration, difficulty walking, breathing, and death. The incidence is 1 in 3,000 boys. Females and males are affected, though females are rarely affected and are more often carriers...

.

Alisporivir is under development by Debiopharm

Debiopharm

Debiopharm Group™ is a global biopharmaceutical group of companies comprising Debiopharm S.A., Debio R.P. S.A. , Debioclinic S.A. and the two financial arms Debiomanagement S.A. and Debioinnovation S.A...

 for Japan

Japan

Japan is an island nation in East Asia. Located in the Pacific Ocean, it lies to the east of the Sea of Japan, China, North Korea, South Korea and Russia, stretching from the Sea of Okhotsk in the north to the East China Sea and Taiwan in the south...

 and by Novartis

Novartis

Novartis International AG is a multinational pharmaceutical company based in Basel, Switzerland, ranking number three in sales among the world-wide industry...

 for the rest of the world (licence granted by Debiopharm

Debiopharm

Debiopharm Group™ is a global biopharmaceutical group of companies comprising Debiopharm S.A., Debio R.P. S.A. , Debioclinic S.A. and the two financial arms Debiomanagement S.A. and Debioinnovation S.A...

) since February 2010.