David P. Lane
Encyclopedia
Sir David Philip Lane FRS, FRSE FRCPath (born 1952) is a British oncologist. He is best known for his work on the p53
tumour suppressor protein
. Besides his position at the University of Dundee
, he also founded the Cyclacel
biotechnology company and is the Chief Scientist of Cancer Research UK
.
He was made a Knight Bachelor
in 1999. In 2004, he was awarded the Buchanan Medal
.
He is currently serving his 2 year sabbatical from the University of Dundee as the Executive Director of Singapore's A*STAR Institute of Molecular and Cell Biology (IMCB) where he was appointed from 1 August 2004. His wife, Professor Birgette Lane also has an appointment as Principal Investigator at IMCB and she is prominent for her work in Keratins and its mutations that could be the basis for genetic skin disorders. She was later appointed as the Executive Director of The Centre for Molecular Medicine (CMM) on 1 April 2006.
In January 2008, they will be also be returning from their extended sabbatical in Singapore to lead the new Division of Molecular Medicine, which is part of a £6 million investment in the College of Life Sciences at the University of Dundee
.
P53
p53 , is a tumor suppressor protein that in humans is encoded by the TP53 gene. p53 is crucial in multicellular organisms, where it regulates the cell cycle and, thus, functions as a tumor suppressor that is involved in preventing cancer...
tumour suppressor protein
Tumor suppressor gene
A tumor suppressor gene, or anti-oncogene, is a gene that protects a cell from one step on the path to cancer. When this gene is mutated to cause a loss or reduction in its function, the cell can progress to cancer, usually in combination with other genetic changes.-Two-hit hypothesis:Unlike...
. Besides his position at the University of Dundee
University of Dundee
The University of Dundee is a university based in the city and Royal burgh of Dundee on eastern coast of the central Lowlands of Scotland and with a small number of institutions elsewhere....
, he also founded the Cyclacel
Cyclacel
Cyclacel Pharmaceuticals Inc. Major shareholders include Magnetar Financial, Deerfield Management, Baker Brothers Advisors and the Federated Kaufmann Fund....
biotechnology company and is the Chief Scientist of Cancer Research UK
Cancer Research UK
Cancer Research UK is a cancer research and awareness charity in the United Kingdom, formed on 4 February 2002 by the merger of The Cancer Research Campaign and the Imperial Cancer Research Fund. Its aim is to reduce the number of deaths from cancer. As the world's largest independent cancer...
.
He was made a Knight Bachelor
Knight Bachelor
The rank of Knight Bachelor is a part of the British honours system. It is the most basic rank of a man who has been knighted by the monarch but not as a member of one of the organised Orders of Chivalry...
in 1999. In 2004, he was awarded the Buchanan Medal
Buchanan Medal
The Buchanan Medal is awarded by the Royal Society every year "in recognition of distinguished contribution to the medical sciences generally". The award was created in 1897 from a fund to the memory of London physician Sir George Buchanan . It was to be awarded once every five years, but since...
.
He is currently serving his 2 year sabbatical from the University of Dundee as the Executive Director of Singapore's A*STAR Institute of Molecular and Cell Biology (IMCB) where he was appointed from 1 August 2004. His wife, Professor Birgette Lane also has an appointment as Principal Investigator at IMCB and she is prominent for her work in Keratins and its mutations that could be the basis for genetic skin disorders. She was later appointed as the Executive Director of The Centre for Molecular Medicine (CMM) on 1 April 2006.
In January 2008, they will be also be returning from their extended sabbatical in Singapore to lead the new Division of Molecular Medicine, which is part of a £6 million investment in the College of Life Sciences at the University of Dundee
University of Dundee
The University of Dundee is a university based in the city and Royal burgh of Dundee on eastern coast of the central Lowlands of Scotland and with a small number of institutions elsewhere....
.