Pico- is a prefix in the metric system denoting a factor of 10−12 or .Derived from the Italian piccolo, meaning small, this was one of the original 12 prefixes defined in 1960 when the International System of Units was established....
The mole is a unit of measurement used in chemistry to express amounts of a chemical substance, defined as an amount of a substance that contains as many elementary entities as there are atoms in 12 grams of pure carbon-12 , the isotope of carbon with atomic weight 12. This corresponds to a value...
s (10−12 moles) of a specific DNA sequence, known as probe
In molecular biology, a hybridization probe is a fragment of DNA or RNA of variable length , which is used in DNA or RNA samples to detect the presence of nucleotide sequences that are complementary to the sequence in the probe...
s (or reporters). These can be a short section of a gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
or other DNA element that are used to hybridize a cDNA or cRNA sample (called target) under high-stringency conditions.