DNA damage-binding protein
Encyclopedia
DNA damage-binding protein is a protein
complex that is responsible for repair of UV-damaged DNA
. This complex is composed of two protein subunits, a large subunit DDB1
and a small subunit DDB2
. This complex functions in nucleotide excision repair
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
complex that is responsible for repair of UV-damaged DNA
DNA
Deoxyribonucleic acid is a nucleic acid that contains the genetic instructions used in the development and functioning of all known living organisms . The DNA segments that carry this genetic information are called genes, but other DNA sequences have structural purposes, or are involved in...
. This complex is composed of two protein subunits, a large subunit DDB1
DDB1
DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene.- Function :This gene encodes the large subunit of DNA damage-binding protein which is a heterodimer composed of a large and a small subunit. This protein functions in nucleotide excision repair...
and a small subunit DDB2
DDB2
DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.-Interactions:DDB2 has been shown to interact with CUL4A, CUL4B and DDB1.-External Links:* -Further reading:...
. This complex functions in nucleotide excision repair
Nucleotide excision repair
Nucleotide excision repair is a DNA repair mechanism. DNA constantly requires repair due to damage that can occur to bases from a vast variety of sources including chemicals, radiation and other mutagens...
.