Disks large-associated protein 1 (DAP-1), also known as guanylate kinase-associated protein (GKAP) is a protein

Protein

Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...

 that in humans is encoded by the DLGAP1 gene

Gene

A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...

. DAP-1 is known to be highly enriched in synaptosomal preparations of the brain, and present in the post synaptic density This gene encodes the protein called guanylate kinase-associated protein (GKAP). GKAP binds to the SHANK

Shank

Shank is the lower part of the leg; shin.It may also refer to:* Shank , a cut of meat * Shank , an action game* Shank , An LGBT based film* Shank , a thriller set in futuristic London...

 and PSD-95 proteins fascilitating the assembly of the post synaptic density of neurons. Dlgap1 has five 14-amino acid repeats and three Pro-rich portions.

Interactions

DLGAP1 has been shown to interact

Protein-protein interaction

Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with DLG4

DLG4

PSD-95 also known as SAP-90 is a protein that in humans is encoded by the DLG4 gene....

, DLG1

DLG1

Disks large homolog 1 , also known as synapse-associated protein 97 or SAP97, is a protein that in humans is encoded by the SAP97 gene....

, DYNLL2

DYNLL2

Dynein light chain 2, cytoplasmic is a protein that in humans is encoded by the DYNLL2 gene.-Interactions:DYNLL2 has been shown to interact with DLG4, DLGAP1, MYO5A and BMF.-Further reading:...

, SHANK2

SHANK2

SH3 and multiple ankyrin repeat domains protein 2 is a protein that in humans is encoded by the SHANK2 gene. Two alternative splice variants, encoding distinct isoforms, are reported...

 and DYNLL1

DYNLL1

Dynein light chain 1, cytoplasmic is a protein that in humans is encoded by the DYNLL1 gene.-Interactions:DYNLL1 has been shown to interact with DLGAP1, MYO5A, DYNC1I1, BCL2L11, NRF1, IκBα, PAK1, DLG4 and TP53BP1.-Further reading:...

..

The interaction with PSD95 and S-SCAM is mediated by the GUK domain and it has been hypothesized that this might mean it can also interact with other GUK containing proteins.