DLG3
Encyclopedia
Disks large homolog 3 also known as neuroendocrine-DLG or synapse-associated protein 102 (SAP-102) is a protein
that in humans is encoded by the DLG3 gene
. DLG3 is a member of the membrane-associated guanylate kinase
(MAGUK) superfamily of proteins.
with GRIN2C
, PTK2B
, GRIN2A
, GRIN2B
, SYNGAP1
, CRIPT
, DLG4
, EXOC4
, APC
, KCNJ12
and EXOC3
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the DLG3 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. DLG3 is a member of the membrane-associated guanylate kinase
Membrane-associated guanylate kinase
The membrane-associated guanylate kinases are a superfamily of proteins. The MAGUKs are defined by their inclusion of PDZ, SH3 and GUK domains, although many of them also contain regions homologous of CaMKII, WW and L27 domains...
(MAGUK) superfamily of proteins.
Interactions
DLG3 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with GRIN2C
GRIN2C
Glutamate [NMDA] receptor subunit epsilon-3 is a protein that in humans is encoded by the GRIN2C gene.-Interactions:GRIN2C has been shown to interact with DLG4 and DLG3....
, PTK2B
PTK2B
Protein tyrosine kinase 2 beta is an enzyme that in humans is encoded by the PTK2B gene.-Protein:-Interactions:PTK2B has been shown to interact with PTPN11, PTPN6, PITPNM1, Gelsolin, Src, GRIN2A, Ewing sarcoma breakpoint region 1, RB1CC1, TGFB1I1, NPHP1, BCAR1, FYN, DLG4, DLG3, DDEF2, Cbl gene, RAS...
, GRIN2A
GRIN2A
Glutamate [NMDA] receptor subunit epsilon-1 is a protein that in humans is encoded by the GRIN2A gene.-Interactions:GRIN2A has been shown to interact with FYN, DLG4, DLG3, DLG1, Src, PTK2B and Interleukin 16.-Further reading:...
, GRIN2B
GRIN2B
Glutamate [NMDA] receptor subunit epsilon-2 also known as N-methyl D-aspartate receptor subtype 2B is a protein that in humans is encoded by the GRIN2B gene.- Function :...
, SYNGAP1
SYNGAP1
Synaptic Ras GTPase activating protein 1 homolog , also known as SYNGAP1, is a protein which in humans is encoded by the SYNGAP1 gene. SYNGAP1 is a ras GTPase-activating protein that is critical for cognition and synapse function. Mutations in humans cause mental retardation.- Function :Unc51.1 and...
, CRIPT
CRIPT
Cysteine-rich PDZ-binding protein is a protein that in humans is encoded by the CRIPT gene.-Further reading:...
, DLG4
DLG4
PSD-95 also known as SAP-90 is a protein that in humans is encoded by the DLG4 gene....
, EXOC4
EXOC4
Exocyst complex component 4 is a protein that in humans is encoded by the EXOC4 gene.-Interactions:EXOC4 has been shown to interact with DLG4, EXOC7, GRIN2B, EXOC3 and DLG3.-Further reading:...
, APC
APC (gene)
Adenomatous polyposis coli also known as deleted in polyposis 2.5 is a protein that in humans is encoded by the APC gene. Mutations in the APC gene may result in colorectal cancer....
, KCNJ12
KCNJ12
ATP-sensitive inward rectifier potassium channel 12 is a protein that in humans is encoded by the KCNJ12 gene.-Interactions:KCNJ12 has been shown to interact with LIN7C, DLG4, LIN7B, DLG2, DLG3, DLG1, APBA1, LIN7A and CASK.- External links :...
and EXOC3
EXOC3
Exocyst complex component 3 is a protein that in humans is encoded by the EXOC3 gene.-Interactions:EXOC3 has been shown to interact with DLG3 and EXOC4.-Further reading:...
.