DHA-clozapine
Encyclopedia
DHA-clozapine is an atypical antipsychotic
that has been developed by Protarga. The drug has been created by the association of the fatty acid docosahexaenoic acid
(DHA) with clozapine
. The advantages of this drug are that until the DHA and clozapine are separated, the drug is inactive; once it penetrates the blood brain barrier, the DHA and clozapine are freed from each other slowly by enzymatic activity and therefore more clozapine is liberated where it is needed, rendering the drug much more potent, actively longer in duration, and therefore requiring a much lower dosage, which results in fewer side effects. The drug is not yet available.
Antipsychotic
An antipsychotic is a tranquilizing psychiatric medication primarily used to manage psychosis , particularly in schizophrenia and bipolar disorder. A first generation of antipsychotics, known as typical antipsychotics, was discovered in the 1950s...
that has been developed by Protarga. The drug has been created by the association of the fatty acid docosahexaenoic acid
Docosahexaenoic acid
Docosahexaenoic acid is an omega-3 fatty acid that is a primary structural component of the human brain and retina. In chemical structure, DHA is a carboxylic acid with a 22-carbon chain and six cis double bonds; the first double bond is located at the third carbon from the omega end...
(DHA) with clozapine
Clozapine
Clozapine is an antipsychotic medication used in the treatment of schizophrenia, and is also used off-label in the treatment of bipolar disorder. Wyatt. R and Chew...
. The advantages of this drug are that until the DHA and clozapine are separated, the drug is inactive; once it penetrates the blood brain barrier, the DHA and clozapine are freed from each other slowly by enzymatic activity and therefore more clozapine is liberated where it is needed, rendering the drug much more potent, actively longer in duration, and therefore requiring a much lower dosage, which results in fewer side effects. The drug is not yet available.