Creatine ethyl ester
Encyclopedia
Creatine ethyl ester, also known as creatine ester, cre-ester and CEE, is a substance sold as an aid for athletic performance and for muscle development in bodybuilding
. It is an ethyl
ester
derivative of creatine
, from which it is made. In the body, CEE is converted back into creatine. CEE is said to have a much better absorption rate and a longer half-life
in the body than regular creatine monohydrate, because it is slightly more lipophilic. It is also proposed to bypass the creatine transporter, thereby increasing skeletal muscle uptake of creatine and leading to an increased ability to regenerate ATP. However, in a published study comparing the two, CEE was not as effective at increasing serum and muscle creatine levels or in improving body composition, muscle mass, strength, and power.
As a supplement, the compound was developed, patented and licensed through UNeMed
, the technology transfer entity of the University of Nebraska Medical Center
, and is sold under numerous brand names.
Bodybuilding
Bodybuilding is a form of body modification involving intensive muscle hypertrophy. An individual who engages in this activity is referred to as a bodybuilder. In competitive and professional bodybuilding, bodybuilders display their physiques to a panel of judges, who assign points based on their...
. It is an ethyl
Ethyl group
In chemistry, an ethyl group is an alkyl substituent derived from ethane . It has the formula -C2H5 and is very often abbreviated -Et.Ethylation is the formation of a compound by introduction of the ethyl functional group, C2H5....
ester
Ester
Esters are chemical compounds derived by reacting an oxoacid with a hydroxyl compound such as an alcohol or phenol. Esters are usually derived from an inorganic acid or organic acid in which at least one -OH group is replaced by an -O-alkyl group, and most commonly from carboxylic acids and...
derivative of creatine
Creatine supplements
Creatine supplements are athletic aids used to increase high-intensity athletic performance. Though researchers have known of the use of creatine as an energy source by skeletal muscles since the beginning of the 20th century, they were popularized as a performance-enhancing supplement in...
, from which it is made. In the body, CEE is converted back into creatine. CEE is said to have a much better absorption rate and a longer half-life
Half-life
Half-life, abbreviated t½, is the period of time it takes for the amount of a substance undergoing decay to decrease by half. The name was originally used to describe a characteristic of unstable atoms , but it may apply to any quantity which follows a set-rate decay.The original term, dating to...
in the body than regular creatine monohydrate, because it is slightly more lipophilic. It is also proposed to bypass the creatine transporter, thereby increasing skeletal muscle uptake of creatine and leading to an increased ability to regenerate ATP. However, in a published study comparing the two, CEE was not as effective at increasing serum and muscle creatine levels or in improving body composition, muscle mass, strength, and power.
As a supplement, the compound was developed, patented and licensed through UNeMed
UNeMed
UNeMed Corporation is the technology transfer entity of the University of Nebraska Medical Center. Through licensing and other cooperative agreements, UNeMed builds relationships with industry partners to transfer UNMC intellectual property from the laboratory to the marketplace.-History:Owned by...
, the technology transfer entity of the University of Nebraska Medical Center
University of Nebraska Medical Center
The University of Nebraska Medical Center is a public academic health sciences center located on 42nd and Emile Streets in Midtown Omaha, Nebraska. UNMC is the only public academic health science center in Nebraska.-Academics and rankings:...
, and is sold under numerous brand names.