Cotton fever
Encyclopedia
Cotton fever is a syndrome
that is often associated with intravenous drug use, specifically the use of cotton
to filter drugs like heroin. The cause of the condition has been established to be the endotoxin
shed by the bacteria Enterobacter
agglomerans which colonizes cotton plants. A condition very similar to cotton fever was described in the early 1940s among cotton-farm workers. The term cotton fever was coined in 1975 after the syndrome was recognized in intravenous drug users. However, some sources have attributed the symptoms of cotton fever with simple sepsis occasioned by unsafe and unsanitary drug injection practices. This is borne out by the fact cotton fever occurs in equal spread with all injectable drug users, irrespective of if they used cotton as a filter or not.
, they may include headache
s, malaise
, chills, nausea
shortness of breath, and tachycardia
. The fever itself usually reaches 38.5–40.3 °C (101.3–104.5 F) within the first hour. The symptoms of cotton fever resemble those of sepsis
and patients can be initially misdiagnosed upon admission to a hospital.
Syndrome
In medicine and psychology, a syndrome is the association of several clinically recognizable features, signs , symptoms , phenomena or characteristics that often occur together, so that the presence of one or more features alerts the physician to the possible presence of the others...
that is often associated with intravenous drug use, specifically the use of cotton
Cotton
Cotton is a soft, fluffy staple fiber that grows in a boll, or protective capsule, around the seeds of cotton plants of the genus Gossypium. The fiber is almost pure cellulose. The botanical purpose of cotton fiber is to aid in seed dispersal....
to filter drugs like heroin. The cause of the condition has been established to be the endotoxin
Endotoxin
Endotoxins are toxins associated with some Gram-negative bacteria. An "endotoxin" is a toxin that is a structural molecule of the bacteria that is recognized by the immune system.-Gram negative:...
shed by the bacteria Enterobacter
Enterobacter
Enterobacter is a genus of common Gram-negative, facultatively-anaerobic, rod-shaped bacteria of the family Enterobacteriaceae. Several strains of the these bacteria are pathogenic and cause opportunistic infections in immunocompromised hosts and in those who are on mechanical ventilation...
agglomerans which colonizes cotton plants. A condition very similar to cotton fever was described in the early 1940s among cotton-farm workers. The term cotton fever was coined in 1975 after the syndrome was recognized in intravenous drug users. However, some sources have attributed the symptoms of cotton fever with simple sepsis occasioned by unsafe and unsanitary drug injection practices. This is borne out by the fact cotton fever occurs in equal spread with all injectable drug users, irrespective of if they used cotton as a filter or not.
Symptoms
Symptoms of cotton fever usually appear with 10–20 minutes after injection. In addition to feverFever
Fever is a common medical sign characterized by an elevation of temperature above the normal range of due to an increase in the body temperature regulatory set-point. This increase in set-point triggers increased muscle tone and shivering.As a person's temperature increases, there is, in...
, they may include headache
Headache
A headache or cephalalgia is pain anywhere in the region of the head or neck. It can be a symptom of a number of different conditions of the head and neck. The brain tissue itself is not sensitive to pain because it lacks pain receptors. Rather, the pain is caused by disturbance of the...
s, malaise
Malaise
Malaise is a feeling of general discomfort or uneasiness, of being "out of sorts", often the first indication of an infection or other disease. Malaise is often defined in medicinal research as a "general feeling of being unwell"...
, chills, nausea
Nausea
Nausea , is a sensation of unease and discomfort in the upper stomach with an involuntary urge to vomit. It often, but not always, precedes vomiting...
shortness of breath, and tachycardia
Tachycardia
Tachycardia comes from the Greek words tachys and kardia . Tachycardia typically refers to a heart rate that exceeds the normal range for a resting heart rate...
. The fever itself usually reaches 38.5–40.3 °C (101.3–104.5 F) within the first hour. The symptoms of cotton fever resemble those of sepsis
Sepsis
Sepsis is a potentially deadly medical condition that is characterized by a whole-body inflammatory state and the presence of a known or suspected infection. The body may develop this inflammatory response by the immune system to microbes in the blood, urine, lungs, skin, or other tissues...
and patients can be initially misdiagnosed upon admission to a hospital.