Corneal dystrophy of Bowman layer, type II
Encyclopedia
Corneal dystrophy of Bowman layer, type II (CDB2), or, more commonly, Thiel-Behnke dystrophy (TBCD), is a rare form of human corneal dystrophy affecting the layer
that supports corneal epithelium
. Some cases of it are linked to chromosome 10q24
, others stem from a mutation in the TGFBI
gene.
The dystrophy was first described in 1967 and initially suspected to denote the same entity as the earlier-described Reis-Bucklers dystrophy, but following a study in 1995 by Kuchle et al. the two look-alike dystrophies were deemed separate disorders.
Bowman's membrane
The Bowman's membrane is a smooth layer in the eye. It is located between the superficial epithelium and the stroma in the cornea. It is composed of strong collagen fibers and helps the cornea maintain its shape...
that supports corneal epithelium
Corneal epithelium
The corneal epithelium is made up of epithelial tissue and covers the front of the cornea. It acts as a barrier to protect the cornea, resisting the free flow of fluids from the tears, and prevents bacteria from entering the epithelium and corneal stroma.The corneal epithelium consists of several...
. Some cases of it are linked to chromosome 10q24
Chromosome 10 (human)
125px|rightChromosome 10 is one of the 23 pairs of chromosomes in humans. People normally have two copies of this chromosome. Chromosome 10 spans about 135 million base pairs and represents between 4 and 4.5 percent of the total DNA in cells.Identifying genes on each chromosome is an active area...
, others stem from a mutation in the TGFBI
TGFBI
Transforming growth factor, beta-induced, 68kDa, also known as TGFBI , is a protein which in humans is encoded by the TGFBI gene.- Function :...
gene.
The dystrophy was first described in 1967 and initially suspected to denote the same entity as the earlier-described Reis-Bucklers dystrophy, but following a study in 1995 by Kuchle et al. the two look-alike dystrophies were deemed separate disorders.