Congenital estrogen deficiency
Encyclopedia
Congenital estrogen deficiency is a genetic condition by which the body is unable to produce or use estrogen
s.
Conditions include:
Estrogen
Estrogens , oestrogens , or œstrogens, are a group of compounds named for their importance in the estrous cycle of humans and other animals. They are the primary female sex hormones. Natural estrogens are steroid hormones, while some synthetic ones are non-steroidal...
s.
Conditions include:
- Aromatase deficiencyAromatase deficiencyAromatase deficiency is a condition resulting from insufficient production of the enzyme aromatase, which can lead to inappropriate virilization.One notable feature is that it can also affect the mother during gestation that resolves after birth...
, a condition where the enzyme aromatase is absent and androgens are not converted to estrogens. - Estrogen insensitivity syndromeEstrogen insensitivity syndromeThe estrogen insensitivity syndrome or estrogen resistance is a form of congenital estrogen deficiency caused by a defective estrogen receptor . Thus, estrogens cannot be recognized and initiate their biological action....
, a condition where the estrogen receptorEstrogen receptorEstrogen receptor refers to a group of receptors that are activated by the hormone 17β-estradiol . Two types of estrogen receptor exist: ER, which is a member of the nuclear hormone family of intracellular receptors, and the estrogen G protein-coupled receptor GPR30 , which is a G protein-coupled...
is defective and estrogen are not biologically active.