Complement component 1S
Encyclopedia
Complement component 1S is a protein involved in the complement system
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C1s cleaves C4
, which eventually leads to the production of the C4b-C2a form of C3-convertase
.
Complement system
The complement system helps or “complements” the ability of antibodies and phagocytic cells to clear pathogens from an organism. It is part of the immune system called the innate immune system that is not adaptable and does not change over the course of an individual's lifetime...
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C1s cleaves C4
Complement component 4
Complement component 4 is a protein involved in the complement system.It is cleaved into proteins 4a and 4b.* C4a is an anaphylatoxin.* C4b forms part of C3-convertase, in conjunction with 2a:* C4b can bind CR1....
, which eventually leads to the production of the C4b-C2a form of C3-convertase
C3-convertase
There are two forms of C3-convertase .* The first is an enzyme composed of the C4b-C2a complex, which forms during the classical or lectin pathways of the complement system. It is formed when C1s cleaves off a small peptide fragment of C2 C2b from a membrane-bound C4b-C2a complex.* The second...
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