CommunityTSC
Encyclopedia
CommunityTSC Drug Design Optimization Lab (D2OL), ended on April 15, 2009, was a distributed computing
project developed by the Rothberg Institute For Childhood Diseases
to test drug candidates interaction with a target molecule that is essential to the spread of the disease under scrutiny. By evaluating the energy level released by binding a small molecule drug candidate to the surface of a larger Target molecule (D2OL) determines the fitness of the particular candidate to a region of the Target structure known as the Active Site. This process is referred to as Docking the drug candidate to the target.
The Rothberg Institute For Childhood Diseases is a non-profit organization dedicated to finding a cure for children suffering from Tuberous Sclerosis Complex (TSC), and operates at the intersection of modern biology
, computer science
, and chemistry
.
Distributed computing
Distributed computing is a field of computer science that studies distributed systems. A distributed system consists of multiple autonomous computers that communicate through a computer network. The computers interact with each other in order to achieve a common goal...
project developed by the Rothberg Institute For Childhood Diseases
Rothberg Institute For Childhood Diseases
The Rothberg Institute For Childhood Diseases is a non-profit organization dedicated to finding a cure for children suffering from Tuberous Sclerosis Complex, founded in 2002. It is responsible for the CommunityTSC distributed computing project....
to test drug candidates interaction with a target molecule that is essential to the spread of the disease under scrutiny. By evaluating the energy level released by binding a small molecule drug candidate to the surface of a larger Target molecule (D2OL) determines the fitness of the particular candidate to a region of the Target structure known as the Active Site. This process is referred to as Docking the drug candidate to the target.
The Rothberg Institute For Childhood Diseases is a non-profit organization dedicated to finding a cure for children suffering from Tuberous Sclerosis Complex (TSC), and operates at the intersection of modern biology
Biology
Biology is a natural science concerned with the study of life and living organisms, including their structure, function, growth, origin, evolution, distribution, and taxonomy. Biology is a vast subject containing many subdivisions, topics, and disciplines...
, computer science
Computer science
Computer science or computing science is the study of the theoretical foundations of information and computation and of practical techniques for their implementation and application in computer systems...
, and chemistry
Chemistry
Chemistry is the science of matter, especially its chemical reactions, but also its composition, structure and properties. Chemistry is concerned with atoms and their interactions with other atoms, and particularly with the properties of chemical bonds....
.