Collagen receptor
Encyclopedia
Collagen receptors are membrane proteins that bind the extracellular matrix protein collagen
, the most abundant protein in mammals.. They may enable adhesion between cells and/or propagate signals into the cell.
There are at least eight human collagen receptors. Several of these are Integrin
receptors.
Integrin α1β1 is a heterodimer of large α and β subunits; collagen binds to the MIDAS motif in the α subunit I domain. It preferentially binds collagens IV and VI, but also fibril-forming collagens. Specific binding sites in collagen I and IV have been identified. Functions include: fibroblast proliferation; regulation of collagen synthesis and MMP
expression; response to renal injury.
Integrin α2β1 has a structure similar to Integrin α1β1. It preferentially binds fibril-forming collagens. Specific binding sites in collagen I and III have been identified. Functions include: platelet adhesion - the most abundant receptor for collagen in platelet
s; branching morphogenesis; mast cell activation; keratinocyte adhesion.
Integrin α10β1 structure as above. Preferentially binds collagens IV and VI, but also collagen II. Involved in growth plate morphogenesis and function.
Integrin α11β1 structure as above. Preferentially binds fibril-forming collagens; specific sites in collagen I identified. Functions are not well defined.
DDR1
is a homodimer. It's ectodomain consists of a collagen-binding discoidin domain followed by ~200 residues of unknown structure. It binds fibril-forming collagens and collagen IV, collagen VIII. Functions include: mammary gland development; arterial wound repair; regulation of cell proliferation and MMP expression; kidney function, differentiation and function of leukocytes.
DDR2
structure as above. Binds fibril-forming collagens, collagen X. A specific binding site in collagen II has been identified. Functions include: Chondrocyte proliferation and bone growth; regulation of cell proliferation and MMP expression.
Glycoprotein VI is a heterotetramer with the FcRγ chain. It’s ectodomain contains two IG domains, the first of which binds collagen. It binds fibril-forming collagens; and the synthetic collagen peptide (GPO)10. Functions include: Platelet adhesion and activation - the most important platelet collagen receptor in terms of signaling.
LAIR1
has an ectodomain that consists of a single IG domain. It binds fibril-forming collagens and (GPO)10. It is involved in immune cell regulation.
Mannose receptor
family (MR, PLA2R, DEC-205, Endo180, uPARAP). These have a large ectodomain consisting of cysteine-rich domain, a collagen-binding F2 domain, and eight to ten C-type lectin domains. Binds fibril-forming collagens and collagen IV, as well as gelatin.
Collagen
Collagen is a group of naturally occurring proteins found in animals, especially in the flesh and connective tissues of mammals. It is the main component of connective tissue, and is the most abundant protein in mammals, making up about 25% to 35% of the whole-body protein content...
, the most abundant protein in mammals.. They may enable adhesion between cells and/or propagate signals into the cell.
There are at least eight human collagen receptors. Several of these are Integrin
Integrin
Integrins are receptors that mediate attachment between a cell and the tissues surrounding it, which may be other cells or the ECM. They also play a role in cell signaling and thereby regulate cellular shape, motility, and the cell cycle....
receptors.
Integrin α1β1 is a heterodimer of large α and β subunits; collagen binds to the MIDAS motif in the α subunit I domain. It preferentially binds collagens IV and VI, but also fibril-forming collagens. Specific binding sites in collagen I and IV have been identified. Functions include: fibroblast proliferation; regulation of collagen synthesis and MMP
Matrix metalloproteinase
Matrix metalloproteinases are zinc-dependent endopeptidases; other family members are adamalysins, serralysins, and astacins. The MMPs belong to a larger family of proteases known as the metzincin superfamily....
expression; response to renal injury.
Integrin α2β1 has a structure similar to Integrin α1β1. It preferentially binds fibril-forming collagens. Specific binding sites in collagen I and III have been identified. Functions include: platelet adhesion - the most abundant receptor for collagen in platelet
Platelet
Platelets, or thrombocytes , are small,irregularly shaped clear cell fragments , 2–3 µm in diameter, which are derived from fragmentation of precursor megakaryocytes. The average lifespan of a platelet is normally just 5 to 9 days...
s; branching morphogenesis; mast cell activation; keratinocyte adhesion.
Integrin α10β1 structure as above. Preferentially binds collagens IV and VI, but also collagen II. Involved in growth plate morphogenesis and function.
Integrin α11β1 structure as above. Preferentially binds fibril-forming collagens; specific sites in collagen I identified. Functions are not well defined.
DDR1
DDR1
For the older type of computer memory, see DDR SDRAM.Discoidin domain receptor family, member 1, also known as DDR1 or CD167a , is a human gene.-Further reading:...
is a homodimer. It's ectodomain consists of a collagen-binding discoidin domain followed by ~200 residues of unknown structure. It binds fibril-forming collagens and collagen IV, collagen VIII. Functions include: mammary gland development; arterial wound repair; regulation of cell proliferation and MMP expression; kidney function, differentiation and function of leukocytes.
DDR2
DDR2
DDR2 may refer to:* DDR2 SDRAM, the computer memory technology* Dance Dance Revolution 2ndMix, the video game* DDR2 , a human gene...
structure as above. Binds fibril-forming collagens, collagen X. A specific binding site in collagen II has been identified. Functions include: Chondrocyte proliferation and bone growth; regulation of cell proliferation and MMP expression.
Glycoprotein VI is a heterotetramer with the FcRγ chain. It’s ectodomain contains two IG domains, the first of which binds collagen. It binds fibril-forming collagens; and the synthetic collagen peptide (GPO)10. Functions include: Platelet adhesion and activation - the most important platelet collagen receptor in terms of signaling.
LAIR1
LAIR1
Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene. LAIR1 has also been designated as CD305 .-Interactions:...
has an ectodomain that consists of a single IG domain. It binds fibril-forming collagens and (GPO)10. It is involved in immune cell regulation.
Mannose receptor
Mannose receptor
The mannose receptor is a C-type lectin carbohydrate binding protein primarily present on the surface of macrophages and dendritic cells. It helps recognize pathogens that have mannose on their surface, and triggers one pathway of the complement system....
family (MR, PLA2R, DEC-205, Endo180, uPARAP). These have a large ectodomain consisting of cysteine-rich domain, a collagen-binding F2 domain, and eight to ten C-type lectin domains. Binds fibril-forming collagens and collagen IV, as well as gelatin.