Co-amilofruse is a non-proprietary name used to denote a combination of amiloride

Amiloride

Amiloride is a potassium-sparing diuretic, first approved for use in 1967 , used in the management of hypertension and congestive heart failure. Amiloride was also tested as treatment of cystic fibrosis, but it was revealed inefficient in vivo due to it's short time of action, therefore...

 and the formerly named frusemide (now the INN

International Nonproprietary Name

An International Nonproprietary Name is the official nonproprietary or generic name given to a pharmaceutical substance, as designated by the World Health Organization...

 termed furosemide). Co-amilofruse in the treatment of fluid retention (oedema), either in the legs (peripheral edema

Peripheral edema

Peripheral edema is the swelling of tissues, usually in the lower limbs, due to the accumulation of fluids.The condition is commonly associated with aging, but can be caused by many other conditions, including congestive heart failure, trauma, alcoholism, altitude sickness, pregnancy,...

) or on the lungs (pulmonary oedema). The stronger furosemide loop diuretic

Loop diuretic

Loop diuretics are diuretics that act on the ascending loop of Henle in the kidney. They are primarily used in medicine to treat hypertension and edema often due to congestive heart failure or renal insufficiency...

 has a tendency to cause low potassium levels (hypokalaemia) that may be prevented by the potassium-sparing effects of amiloride.

Formulation

Two strengths of co-amilofruse are available:

• 2.5 mg amiloride with 20 mg furosemide, BAN of Co-amilofruse 2.5/20 (brand name Frumil LS)
• 5 mg amiloride with 40 mg furosemide, BAN of Co-amilofruse 5/4-0 (brand name Frumil)