Class II PI 3-kinases
Encyclopedia
Class II PI 3-kinases are a subgroup of the enzyme family, phosphoinositide 3-kinase
that share a common protein domain structure, substrate specificity and method of activation.
Class II PI 3-kinases were the most recently identified class of PI 3-kinases and little is currently known about these enzymes.
There are three class II PI 3-kinase isoforms expressed in mammalian cells;
Phosphoinositide 3-kinase
Phosphatidylinositol 3-kinases are a family of enzymes involved in cellular functions such as cell growth, proliferation, differentiation, motility, survival and intracellular trafficking, which in turn are involved in cancer. In response to lipopolysaccharide, PI3K phosphorylates p65, inducing...
that share a common protein domain structure, substrate specificity and method of activation.
Class II PI 3-kinases were the most recently identified class of PI 3-kinases and little is currently known about these enzymes.
There are three class II PI 3-kinase isoforms expressed in mammalian cells;
- PI3K-C2α
- PI3K-C2β
- PI3K-C2γ