Christopher E. Rudd
Encyclopedia
Christopher Edward Rudd, PhD, DSc., FRCPath, FMedSci (born November 2, 1953) is a Canadian-born immunologist-biochemist
credited with having had a major impact on the understanding of the intracellular signals that control T-cell immunity. Rudd was the first to discover that intracellular protein kinases interact with surface receptors. He showed that the T-cell co-receptors CD4 (also the receptor for the human immunodeficiency virus, HIV-1) and CD8 on T-cells interact with protein-tyrosine kinase p56lck. His discovery provided a role for members of the proto-oncogene pp60src kinase family in normal cell signalling. There are numerous receptors that now known to use intracellular kinases in the regulation of cell growth. The CD4- and CD8-p56lck complexes are also widely accepted as the initiators of T-cell activation. They are activated and control T-cell responses to foreign pathogens, transplants and cancer.
Born in Toronto
, Canada, he was educated at Jesuit-run Brebeuf College School
. He received his PhD and DSc from University College, London and has held faculty positions at Harvard Medical School
and Imperial College London
. He is the past recipient of awards from the Cancer Research Institute (New York) and was a Scholar of the Leukemia Society of America. Rudd is presently a Principal Research Fellow with the Wellcome Trust London, and a Professor of Molecular Immunology at the University of Cambridge
.
Biochemist
Biochemists are scientists who are trained in biochemistry. Typical biochemists study chemical processes and chemical transformations in living organisms. The prefix of "bio" in "biochemist" can be understood as a fusion of "biological chemist."-Role:...
credited with having had a major impact on the understanding of the intracellular signals that control T-cell immunity. Rudd was the first to discover that intracellular protein kinases interact with surface receptors. He showed that the T-cell co-receptors CD4 (also the receptor for the human immunodeficiency virus, HIV-1) and CD8 on T-cells interact with protein-tyrosine kinase p56lck. His discovery provided a role for members of the proto-oncogene pp60src kinase family in normal cell signalling. There are numerous receptors that now known to use intracellular kinases in the regulation of cell growth. The CD4- and CD8-p56lck complexes are also widely accepted as the initiators of T-cell activation. They are activated and control T-cell responses to foreign pathogens, transplants and cancer.
Born in Toronto
Toronto
Toronto is the provincial capital of Ontario and the largest city in Canada. It is located in Southern Ontario on the northwestern shore of Lake Ontario. A relatively modern city, Toronto's history dates back to the late-18th century, when its land was first purchased by the British monarchy from...
, Canada, he was educated at Jesuit-run Brebeuf College School
Brebeuf College School
Brebeuf College School is a Roman Catholic all-boys' high school in Toronto founded by the Jesuits in 1963 and associated with the Presentation Brothers since 1984...
. He received his PhD and DSc from University College, London and has held faculty positions at Harvard Medical School
Harvard Medical School
Harvard Medical School is the graduate medical school of Harvard University. It is located in the Longwood Medical Area of the Mission Hill neighborhood of Boston, Massachusetts....
and Imperial College London
Imperial College London
Imperial College London is a public research university located in London, United Kingdom, specialising in science, engineering, business and medicine...
. He is the past recipient of awards from the Cancer Research Institute (New York) and was a Scholar of the Leukemia Society of America. Rudd is presently a Principal Research Fellow with the Wellcome Trust London, and a Professor of Molecular Immunology at the University of Cambridge
University of Cambridge
The University of Cambridge is a public research university located in Cambridge, United Kingdom. It is the second-oldest university in both the United Kingdom and the English-speaking world , and the seventh-oldest globally...
.