Chlorophenylbiguanide
Encyclopedia
Chlorophenylbiguanide
Chlorophenylbiguanide (1-(3-Chlorophenylbiguanide, m-CPBG) is a selective agonist
for the 5HT3 receptor
. It has anxiogenic
, emetic and hypothermic
effects in animal studies.
Chlorophenylbiguanide (1-(3-Chlorophenylbiguanide, m-CPBG) is a selective agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
for the 5HT3 receptor
5-HT3 receptor
The 5-HT3 receptor is a member of the superfamily of ligand-gated ion channels, a superfamily that also includes the neuronal nicotinic acetylcholine receptors , and the inhibitory neurotransmitter receptors for GABA and glycine...
. It has anxiogenic
Anxiogenic
An anxiogenic substance is one that causes anxiety. Anxiogenic effects can be measured by, for example, the hole-board test in rats and mice. A number of agents are used to provoke anxiety or panic in experimental models...
, emetic and hypothermic
Hypothermia
Hypothermia is a condition in which core temperature drops below the required temperature for normal metabolism and body functions which is defined as . Body temperature is usually maintained near a constant level of through biologic homeostasis or thermoregulation...
effects in animal studies.