Chemerin Peptides are short peptide

Peptide

Peptides are short polymers of amino acid monomers linked by peptide bonds. They are distinguished from proteins on the basis of size, typically containing less than 50 monomer units. The shortest peptides are dipeptides, consisting of two amino acids joined by a single peptide bond...

s (on the order of 9 amino acids) that are produced from the carboxyl terminus of the chemokine chemerin

Chemerin

Chemerin, also known as retinoic acid receptor responder protein 2 , tazarotene-induced gene 2 protein , or RAR-responsive protein TIG2 is a protein that in humans is encoded by the RARRES2 gene.- Function :...

. They display the same activities as chemerin ,although at higher efficacy and potency.

A particular synthetic chemerin-derived peptide, termed C15, was developed at Oxford University. It showed anti-inflammatory activities. Intraperitoneal administration of C15 (0.32 ng/kg) to mice before zymosan challenge conferred significant protection against zymosan-induced peritonitis, suppressing neutrophil (63%) and monocyte (62%) recruitment with a concomitant reduction in proinflammatory mediator expression.

C15 was found to promote phagocytosis and efferocytosis in peritoneal macrophages at picomolar concentrations. C15 enhanced macrophage clearance of microbial particles and apoptotic cells by factor of 360% in vitro