Cellular microarray
Encyclopedia
A cellular microarray, is a laboratory
tool that allows for the multiplex
interrogation of living cells
on the surface of a solid support. The support, sometimes called a "chip", is spotted with varying materials, such as antibodies, proteins, or lipids, which can interact with the cells, leading to their capture on specific spots. Combinations of different materials can be spotted in a given area, allowing not only cellular capture, when a specific interaction exists, but also the triggering of a cellular response, change in phenotype
, or detection of a response from the cell, such as a specific secreted
factor. An example of cellular microarrays are PMHC Cellular Microarrays.
Cellular microarrays were developed by Daniel Chen, Yoav Soen, Dan Kraft, Patrick Brown and Mark Davis at Stanford University Medical Center
.
Laboratory
A laboratory is a facility that provides controlled conditions in which scientific research, experiments, and measurement may be performed. The title of laboratory is also used for certain other facilities where the processes or equipment used are similar to those in scientific laboratories...
tool that allows for the multiplex
Multiplex (assay)
A multiplex assay is a type of laboratory procedure that simultaneously measures multiple analytes in a single assay. It is distinguished from procedures that measure one or a few analytes at a time...
interrogation of living cells
Cell (biology)
The cell is the basic structural and functional unit of all known living organisms. It is the smallest unit of life that is classified as a living thing, and is often called the building block of life. The Alberts text discusses how the "cellular building blocks" move to shape developing embryos....
on the surface of a solid support. The support, sometimes called a "chip", is spotted with varying materials, such as antibodies, proteins, or lipids, which can interact with the cells, leading to their capture on specific spots. Combinations of different materials can be spotted in a given area, allowing not only cellular capture, when a specific interaction exists, but also the triggering of a cellular response, change in phenotype
Phenotype
A phenotype is an organism's observable characteristics or traits: such as its morphology, development, biochemical or physiological properties, behavior, and products of behavior...
, or detection of a response from the cell, such as a specific secreted
Secretion
Secretion is the process of elaborating, releasing, and oozing chemicals, or a secreted chemical substance from a cell or gland. In contrast to excretion, the substance may have a certain function, rather than being a waste product...
factor. An example of cellular microarrays are PMHC Cellular Microarrays.
Cellular microarrays were developed by Daniel Chen, Yoav Soen, Dan Kraft, Patrick Brown and Mark Davis at Stanford University Medical Center
Stanford University Medical Center
Stanford University Medical Center represents the Stanford Hospital and the Lucile Packard Children's Hospital and is located at 300 Pasteur Drive in Stanford, California. Stanford Hospital provides both general acute care services and tertiary medical care for patients locally, nationally and...
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