Carmofur or HCFU (1-hexylcarbamoyl-5-fluorouracil) is a pyrimidine analogue

Pyrimidine analogue

Pyrimidine analogues are antimetabolites which mimic the structure of metabolic pyrimidines.-Examples:Examples include:* 5-fluorouracil which inhibits thymidylate synthase.* Floxuridine * Cytosine arabinoside...

 used as an antineoplastic agent. It is a derivative of fluorouracil

Fluorouracil

Fluorouracil is a drug that is a pyrimidine analog which is used in the treatment of cancer. It is a suicide inhibitor and works through irreversible inhibition of thymidylate synthase. It belongs to the family of drugs called antimetabolites...

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Colorectal Cancer

Carmofur, in its oral form, has also been used as adjuvant chemotherapy for curatively resected colorectal cancer patients. Trials and meta-analyses have confirmed that the drug is effective on patients with this cancer type, extending their survival.