CJ-033,466
Encyclopedia
CJ-033,466 is a drug which acts as a potent and selective 5-HT4 serotonin
receptor
partial agonist
. In animal tests it stimulated gastrointestinal motility with 30 times the potency of cisapride
, and with lower affinity for the hERG
channel.
Serotonin
Serotonin or 5-hydroxytryptamine is a monoamine neurotransmitter. Biochemically derived from tryptophan, serotonin is primarily found in the gastrointestinal tract, platelets, and in the central nervous system of animals including humans...
receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
partial agonist
Partial agonist
Partial agonists bind and activate a given receptor, but have only partial efficacy at the receptor relative to a full agonist...
. In animal tests it stimulated gastrointestinal motility with 30 times the potency of cisapride
Cisapride
Cisapride is a gastroprokinetic agent, a drug which increases motility in the upper gastrointestinal tract. It acts directly as a serotonin 5-HT4 receptor agonist and indirectly as a parasympathomimetic. Stimulation of the serotonin receptors increases acetylcholine release in the enteric nervous...
, and with lower affinity for the hERG
HERG
hERG is a gene that codes for a protein known as Kv11.1 potassium ion channel...
channel.