CHRNA10
Encyclopedia
Neuronal acetylcholine receptor subunit alpha-10 also known as cholinergic receptor nicotinic alpha 10 is a protein
that in humans is encoded by the CHRNA10 gene
. The protein
encoded by this gene is a subunit of the nicotinic acetylcholine receptor
(nAchR).
This nAchR subunit is required for the normal function of the olivocochlear system
which is part of the auditory system
. Furthermore selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin
RgIA has been shown to be analgesic in an animal model of nerve injury
pain.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the CHRNA10 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. The protein
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
encoded by this gene is a subunit of the nicotinic acetylcholine receptor
Nicotinic acetylcholine receptor
Nicotinic acetylcholine receptors, or nAChRs, are cholinergic receptors that form ligand-gated ion channels in the plasma membranes of certain neurons and on the postsynaptic side of the neuromuscular junction...
(nAchR).
This nAchR subunit is required for the normal function of the olivocochlear system
Olivocochlear system
The olivocochlear system is a component of the auditory system involved with the descending control of the cochlea. Its nerve fibres, the olivocochlear bundle , form part of the vestibulocochlear nerve , and project from the superior olivary complex in the brainstem to the cochlea.-Cell bodies of...
which is part of the auditory system
Auditory system
The auditory system is the sensory system for the sense of hearing.- Outer ear :The folds of cartilage surrounding the ear canal are called the pinna...
. Furthermore selective block of α9α10 nicotinic acetylcholine receptors by the conotoxin
Conotoxin
A conotoxin is one of a group of neurotoxic peptides isolated from the venom of the marine cone snail, genus Conus.Conotoxins, which are peptides consisting of 10 to 30 amino acid residues, typically have one or more disulfide bonds. Conotoxins have a variety of mechanisms of actions, most of...
RgIA has been shown to be analgesic in an animal model of nerve injury
Nerve injury
Nerve injury is injury to nervous tissue. There is no single classification system that can describe all the many variations of nerve injury. Most systems attempt to correlate the degree of injury with symptoms, pathology and prognosis...
pain.