CHKB (gene)
Encyclopedia
Choline kinase beta is a protein
encoded by the CHKB gene
. This gene is found on chromosome 22 in humans.
Choline kinase
(CK) and ethanolamine kinase
(EK) catalyze the phosphorylation of choline
/ethanolamine
to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family
; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
encoded by the CHKB gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
. This gene is found on chromosome 22 in humans.
Choline kinase
Choline kinase
Choline Kinase is an enzyme which catalyzes the first reaction in the choline pathway for phosphatidylcholine biosynthesis.This reaction involves the transfer of a phosphate group from ATP to choline in order to form phosphocholine.Thus, the two substrates of this enzyme are ATP and choline,...
(CK) and ethanolamine kinase
Ethanolamine kinase
In enzymology, an ethanolamine kinase is an enzyme that catalyzes the chemical reactionThus, the two substrates of this enzyme are ATP and ethanolamine, whereas its two products are ADP and O-phosphoethanolamine....
(EK) catalyze the phosphorylation of choline
Choline
Choline is a water-soluble essential nutrient. It is usually grouped within the B-complex vitamins. Choline generally refers to the various quaternary ammonium salts containing the N,N,N-trimethylethanolammonium cation....
/ethanolamine
Ethanolamine
Ethanolamine, also called 2-aminoethanol or monoethanolamine , is an organic chemical compound that is both a primary amine and a primary alcohol . Like other amines, monoethanolamine acts as a weak base...
to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family
Choline/ethanolamine kinase family
In molecular biology, the choline/ethanolamine kinase family includes choline kinase and ethanolamine kinase .Ethanolamine and choline are major membrane phospholipids, in the form of glycerophosphoethanolamine and glycerophosphocholine. Ethanolamine is also a component of the...
; however, its exact function is not known. At least two transcript variants encoding two different isoforms have been found for this gene, and one of the transcripts is bicistronic.