CECXG is a research drug which acts as a potent and selective antagonist for the group II metabotropic glutamate receptors (mGluR_2/3

Metabotropic glutamate receptor

The metabotropic glutamate receptors, or mGluRs, are a type of glutamate receptor that are active through an indirect metabotropic process. They are members of the group C family of G-protein-coupled receptors, or GPCRs...

), with reasonable selectivity for mGluR₃. While it is some five times less potent than LY-341,495

LY-341,495

LY-341,495 is a research drug developed by the pharmaceutical company Eli Lilly, which acts as a potent and selective orthosteric antagonist for the group II metabotropic glutamate receptors ....

 at mGluR₃, it has 38x higher affinity for mGluR₃

Metabotropic glutamate receptor 3

Metabotropic glutamate receptor 3 is a protein that in humans is encoded by the GRM3 gene.-Ligands:Though truly mGluR3 selective agents still await their discovery, mixed mGluR2/3 ligands with selectivity over other mGluR-subtypes are known...

 over mGluR₂

Metabotropic glutamate receptor 2

Metabotropic glutamate receptor 2 is a protein that in humans is encoded by the GRM2 gene.-PAMs:The development of subtype-2-selective positive allosteric modulators experienced steady advance in recent years...

, making it one of the few ligands available that is able to distinguish between these two closely related receptor subtypes.