CD18
Encyclopedia
Integrin beta-2 is a protein
that in humans is encoded by the ITGB2 gene
.
It is the beta subunit of four different structures:
with ICAM-1
, FHL2
, PSCD1
and GNB2L1
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the ITGB2 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
It is the beta subunit of four different structures:
- LFA-1LFA-1Lymphocyte function-associated antigen 1, also known as LFA-1 is found on all T-cells and also on B-cells, macrophages and neutrophils and is involved in recruitment to the site of infection. It binds to ICAM-1 on antigen-presenting cells and functions as an adhesion molecule. LFA-1 is the first...
(paired with CD11aCD11aIntegrin, alpha L , also known as ITGAL, is a human gene which functions in the immune system. It is involved in cellular adhesion and costimulatory signaling...
) - Macrophage-1 antigenMacrophage-1 antigenMacrophage-1 antigen is a complement receptor consisting of CD11b and CD18.It binds to C3b and C4b.-Function:...
(paired with CD11b) - Integrin alphaXbeta2Integrin alphaXbeta2Integrin alphaXbeta2 is a complement receptor composed of CD11c and CD18....
(paired with CD11cCD11cCD11c, also known as Integrin, alpha X , is a human gene.CD11c is a type I transmembrane protein found at high levels on most human dendritic cells, but also on monocytes, macrophages, neutrophils, and some B cells that induces cellular activation and helps trigger neutrophil respiratory burst;...
) - Integrin alphaDbeta2 (paired with CD11d)
Interactions
CD18 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with ICAM-1
ICAM-1
ICAM-1 also known as CD54 is a protein that in humans is encoded by the ICAM1 gene. This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system...
, FHL2
FHL2
Four and a half LIM domains protein 2 is a protein that in humans is encoded by the FHL2 gene.-Interactions:FHL2 has been shown to interact with Beta-catenin, Titin, Zinc finger and BTB domain-containing protein 16, Integrin, beta 6, Androgen receptor, ITGA7, CREB1, MAPK1, CD49c, ZNF638, BRCA1,...
, PSCD1
PSCD1
Cytohesin-1 is a protein that in humans is encoded by the CYTH1 gene.-Interactions:PSCD1 has been shown to interact with TRIM23, ARFRP1 and CD18.-Further reading:...
and GNB2L1
GNB2L1
Guanine nucleotide-binding protein subunit beta-2-like 1 is a protein that in humans is encoded by the GNB2L1 gene.-Interactions:GNB2L1 has been shown to interact with PDE4D, STAT1, Tyrosine kinase 2, Src, Androgen receptor, AGTRAP, Janus kinase 1, FYN, Cyclin A1, IFNAR2, PRKCE, P73, RAS p21...
.
Further reading
External links
- ITGB2 Info with links in the Cell Migration Gateway