CD120 also known as the tumor necrosis factor receptor (TNFR). This protein is a member of the tumor necrosis factor receptor

Tumor necrosis factor receptor

A tumor necrosis factor receptor , or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors . The receptor cooperates with an adaptor protein , which is important in determining the outcome of the response A tumor necrosis factor receptor (TNFR), or death receptor, is a...

 superfamily.

Receptor subtypes

There are two variants of the receptor, each encoded by a separate gene:

• CD120a - TNFR1 - TNFRSF1A
  TNFRSF1A
  Tumor necrosis factor receptor superfamily member 1A is a protein that in humans is encoded by the TNFRSF1A gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1B. This protein is one of the major receptors for the tumor...
  
  
• CD120b - TNFR2 - TNFRSF1B
  TNFRSF1B
  Tumor necrosis factor receptor superfamily member 1B is a protein that in humans is encoded by the TNFRSF1B gene. The protein encoded by this gene is a member of the Tumor necrosis factor receptor superfamily, which also contains TNFRSF1A. The protein encoded by this gene is a member of the...
  
  

TNFR1 is the receptor type responsible for mediation of TNF-alpha induced sickness behavior, and is involved in neurotoxic processes. Elevated levels of TNFR1 has been found in severe mental disorders.

Signaling pathway