CARD11
Encyclopedia
Caspase recruitment domain-containing protein 11 also known as CARD-containing MAGUK protein 1 (Carma 1) is a protein
that in humans is encoded by the CARD11 gene
.
). This protein has a domain structure similar to that of CARD14
protein. The CARD domains of both proteins have been shown to specifically interact with BCL10
, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation
of BCL10.
with BCL10
.
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
that in humans is encoded by the CARD11 gene
Gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...
.
Function
The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARDCARD domain
Caspase recruitment domains, or Caspase activation and recruitment domains , are interaction motifs found in a wide array of proteins, typically those involved in processes relating to inflammation and apoptosis. These domains mediate the formation of larger protein complexes via direct...
). This protein has a domain structure similar to that of CARD14
CARD14
Caspase recruitment domain-containing protein 14, also known as CARD-containing MAGUK protein 2 , is a protein that in humans is encoded by the CARD14 gene.- Function :...
protein. The CARD domains of both proteins have been shown to specifically interact with BCL10
BCL10
B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.-Interactions:BCL10 has been shown to interact with CARD10, CARD11, MALT1, TRAF2, IKBKG and CARD9.-Further reading:...
, a protein known to function as a positive regulator of cell apoptosis and NF-κB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation
Phosphorylation
Phosphorylation is the addition of a phosphate group to a protein or other organic molecule. Phosphorylation activates or deactivates many protein enzymes....
of BCL10.
Interactions
CARD11 has been shown to interactProtein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...
with BCL10
BCL10
B-cell lymphoma/leukemia 10 is a protein that in humans is encoded by the BCL10 gene.-Interactions:BCL10 has been shown to interact with CARD10, CARD11, MALT1, TRAF2, IKBKG and CARD9.-Further reading:...
.