
CALCRL
Encyclopedia
Calcitonin receptor-like (CALCRL), also known as the calcitonin receptor-like receptor (CRLR), is a human protein
.
related to the calcitonin receptor
. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying protein
s (RAMPs) that are essential for functional activity.
The association of CALCRL with different RAMP proteins produces different receptors:
These receptors are linked to the G protein
Gs
, which activates adenylate cyclase
and activation results in the generation of intracellular
cyclic adenosine monophosphate
(cAMP).
Protein
Proteins are biochemical compounds consisting of one or more polypeptides typically folded into a globular or fibrous form, facilitating a biological function. A polypeptide is a single linear polymer chain of amino acids bonded together by peptide bonds between the carboxyl and amino groups of...
.
Function
The protein encoded by the CALCRL gene is a G protein-coupled receptorG protein-coupled receptor
G protein-coupled receptors , also known as seven-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptor, and G protein-linked receptors , comprise a large protein family of transmembrane receptors that sense molecules outside the cell and activate inside signal...
related to the calcitonin receptor
Calcitonin receptor
The calcitonin receptor is a G protein-coupled receptor that binds the peptide hormone calcitonin and is involved in maintenance of calcium homeostasis, particularly with respect to bone formation and metabolism ....
. CALCRL is linked to one of three single transmembrane domain receptor activity-modifying protein
Receptor activity-modifying protein
Receptor activity-modifying proteins are a class of protein which interact with and modulate the activities of several Class B G Protein-Coupled Receptors including the receptors for secretin, calcitonin , glucagon, and vasoactive intestinal peptide...
s (RAMPs) that are essential for functional activity.
The association of CALCRL with different RAMP proteins produces different receptors:
- with RAMP1RAMP1Receptor activity modifying protein 1 is a protein that in humans is encode by the RAMP1 gene.The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor activity modifying proteins . RAMPs are type I transmembrane proteins with an...
: produces a CGRP receptor - with RAMP2RAMP2Receptor activity modifying protein 2, also known as RAMP2, is a protein which in humans is encoded by the RAMP2 gene.- Function :...
: produces an adrenomedullinAdrenomedullinAdrenomedullin is a peptide associated with pheochromocytoma- a tumour arising from adrenal medulla. It was discovered in 1993.Adrenomedullin is a ubiquitously expressed peptide initially isolated from phaechromyctoma in 1993...
(AM) receptor, designated AM1 - with RAMP3RAMP3Receptor activity modifying protein 3, also known as RAMP3, is a human gene.The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor activity modifying proteins . RAMPs are type I transmembrane proteins with an extracellular N...
: produces a dual CGRP/AM receptor designated AM2
These receptors are linked to the G protein
G protein
G proteins are a family of proteins involved in transmitting chemical signals outside the cell, and causing changes inside the cell. They communicate signals from many hormones, neurotransmitters, and other signaling factors. G protein-coupled receptors are transmembrane receptors...
Gs
Gs alpha subunit
The Gs alpha subunit is a heterotrimeric G protein subunit that activates the cAMP-dependent pathway by activating adenylate cyclase.-Receptors:The G protein-coupled receptors that couple to this kind of G-protein include:...
, which activates adenylate cyclase
Adenylate cyclase
Adenylate cyclase is part of the G protein signalling cascade, which transmits chemical signals from outside the cell across the membrane to the inside of the cell ....
and activation results in the generation of intracellular
Intracellular
Not to be confused with intercellular, meaning "between cells".In cell biology, molecular biology and related fields, the word intracellular means "inside the cell".It is used in contrast to extracellular...
cyclic adenosine monophosphate
Cyclic adenosine monophosphate
Cyclic adenosine monophosphate is a second messenger important in many biological processes...
(cAMP).