Buschke-Ollendorff syndrome
Overview
Laminopathy
Laminopathies are a group of rare genetic disorders caused by mutations in genes encoding proteins of the nuclear lamina. They are included in the more generic term nuclear envelopathies that was coined in 2000 for diseases associated with defects of the nuclear envelope...
associated with LEMD3. It is believed to be inherited in an autosomal
Autosome
An autosome is a chromosome that is not a sex chromosome, or allosome; that is to say, there is an equal number of copies of the chromosome in males and females. For example, in humans, there are 22 pairs of autosomes. In addition to autosomes, there are sex chromosomes, to be specific: X and Y...
dominant manner.
It is named for Abraham Buschke
Abraham Buschke
Abraham Buschke was a Jewish German dermatologist who was a native of Nakel in the Province of Posen. In 1891 he received his doctorate in Berlin, and afterwards was a surgical assistant in Greifswald. Later he worked at dermatological clinics in Breslau under Albert Neisser and in Berlin with...
and Helene Ollendorff Curth who described it in a 45 year old woman. Its frequency is almost 1 case per every 20'000 people and is equally found in both males and females.
Buschke–Ollendorff syndrome is inherited in an autosomal dominant manner.
Quotations
You can't get a big head about [fame]. When people stare at me, they could be whispering to their friend, 'That guy sucks! Have you seen him before? He's horrible.'
Hollywood Minute|Hollywood Minute, Saturday Night Live