Bullous drug reaction
Encyclopedia
Bullous drug reaction most commonly refers to a drug reaction in the erythema multiforme
Erythema multiforme
Erythema multiforme is a skin condition of unknown cause, possibly mediated by deposition of immune complex in the superficial microvasculature of the skin and oral mucous membrane that usually follows an infection or drug exposure...

 group. These are uncommon reactions to medications, with an incidence of 0.4 to 1..2 per million person-years for toxic epidermal necrolysis
Toxic epidermal necrolysis
Toxic epidermal necrolysis is a rare, life-threatening dermatological condition that is usually induced by a reaction to medications...

 and 1.2 to 6.0 per million person-years for Stevens–Johnson syndrome. The primary skin lesions are large erythemas (faintly discernable even after confluence), most often irregularly distributed and of a characteristic purplish-livid color, at times with flaccid blisters.
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