Bisphenol AF
Encyclopedia
Bisphenol AF is a fluorinated organic compound
related to bisphenol A
in which the two methyl groups are replaced with trifluoromethyl
groups.
Whereas BPA binds with human estrogen-related receptor gamma
(ERR-γ), BPAF all but ignores ERR-γ. Instead, BPAF activates ERR-α
and binds to and disables ERR-β
.
Organic compound
An organic compound is any member of a large class of gaseous, liquid, or solid chemical compounds whose molecules contain carbon. For historical reasons discussed below, a few types of carbon-containing compounds such as carbides, carbonates, simple oxides of carbon, and cyanides, as well as the...
related to bisphenol A
Bisphenol A
Bisphenol A is an organic compound with two phenol functional groups. It is used to make polycarbonate plastic and epoxy resins, along with other applications....
in which the two methyl groups are replaced with trifluoromethyl
Trifluoromethyl
Trifluoromethyl is a functional group in organofluorines that has the formula -CF3. The naming of is group is derived from the methyl group , by replacing each hydrogen atom by a fluorine atom. The trifluomethyl group has a significant electronegativity that is often described as being...
groups.
Whereas BPA binds with human estrogen-related receptor gamma
Estrogen-related receptor gamma
Estrogen-related receptor gamma , also known as NR3B3 , is a nuclear receptor that in humans is encoded by the ESRRG gene. It behaves as a constitutive activator of transcription.This protein is a member of nuclear hormone receptor family of steroid hormone receptors...
(ERR-γ), BPAF all but ignores ERR-γ. Instead, BPAF activates ERR-α
Estrogen-related receptor alpha
Estrogen-related receptor alpha , also known as NR3B1 , is a nuclear receptor that in humans is encoded by the ESRRA gene.-Tissue distribution:...
and binds to and disables ERR-β
Estrogen-related receptor beta
Estrogen-related receptor beta , also known as NR3B2 , is a nuclear receptor that in humans is encoded by the ESRRB gene .- Function :...
.