Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme
Enzymes are proteins that catalyze chemical reactions. In enzymatic reactions, the molecules at the beginning of the process, called substrates, are converted into different molecules, called products. Almost all chemical reactions in a biological cell need enzymes in order to occur at rates...

 that in humans is encoded by the BUB1B gene
A gene is a molecular unit of heredity of a living organism. It is a name given to some stretches of DNA and RNA that code for a type of protein or for an RNA chain that has a function in the organism. Living beings depend on genes, as they specify all proteins and functional RNA chains...



BUB1B has been shown to interact
Protein-protein interaction
Protein–protein interactions occur when two or more proteins bind together, often to carry out their biological function. Many of the most important molecular processes in the cell such as DNA replication are carried out by large molecular machines that are built from a large number of protein...

 with AP2B1
AP-2 complex subunit beta is a protein that in humans is encoded by the AP2B1 gene.-Interactions:AP2B1 has been shown to interact with TGF beta receptor 2, AP1M2, BUB1B, LDLRAP1 and Arrestin beta 2.-Further reading:...

Histone deacetylase 1 is an enzyme that in humans is encoded by the HDAC1 gene.-Interactions:HDAC1 has been shown to interact with RAD9A, DNMT3L, MTA1, FKBP3, CDC20, CDH1, Host cell factor C1, BUB3, Nuclear receptor co-repressor 2, IKZF1, Prohibitin, EVI1, DDX5, DNMT3A, Mothers against...

, BUB3
Mitotic checkpoint protein BUB3 is a protein that in humans is encoded by the BUB3 gene.Bub3 is a protein involved with the regulation of the Spindle Assembly Checkpoint ; though BUB3 is non-essential in yeast, it is essential in higher eukaryotes...

, MAD2L1
Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.-Interactions:MAD2L1 has been shown to interact with MAD2L2, CDC20, BUB1B, Estrogen receptor beta, ADAM17, UBD, CDC27 and Mad1....

, Gamma-synuclein
Gamma-synuclein is a protein that in humans is encoded by the SNCG gene.Gamma-synuclein is a synuclein protein found primarily in the peripheral nervous system and retina. It is also detected in the brain, ovarian tumors, and in the olfactory epithelium...

BRCA2 is a protein that in humans is encoded by the BRCA2 gene.BRCA2 orthologs have been identified in most mammals for which complete genome data are available....

 and CDC20
The cell-division cycle protein 20 is an essential regulator of cell division that is encoded by the CDC20 gene in humans. To the best of current knowledge its most important function is to activate the anaphase promoting complex , a large 11-13 subunit complex that initiates chromatid separation...


Further reading

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