BAY 60–6583
Encyclopedia
BAY 60–6583 is a selective adenosine A2B
receptor
agonist
. It has been shown to provide protection from ischemia
(lack of oxygen due to blocked blood supply) in both the heart and kidney of test animals, and has also been shown to be beneficial in treatment of acute lung injury, showing a range of potential applications for selective A2B agonists.
Adenosine A2b receptor
The adenosine A2B receptor, also known as ADORA2B, is a G-protein coupled adenosine receptor, and also denotes the human adenosine A2b receptor gene which encodes it....
receptor
Receptor (biochemistry)
In biochemistry, a receptor is a molecule found on the surface of a cell, which receives specific chemical signals from neighbouring cells or the wider environment within an organism...
agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
. It has been shown to provide protection from ischemia
Ischemia
In medicine, ischemia is a restriction in blood supply, generally due to factors in the blood vessels, with resultant damage or dysfunction of tissue. It may also be spelled ischaemia or ischæmia...
(lack of oxygen due to blocked blood supply) in both the heart and kidney of test animals, and has also been shown to be beneficial in treatment of acute lung injury, showing a range of potential applications for selective A2B agonists.