Avanafil
Encyclopedia
Avanafil is a PDE5 inhibitor
being developed for erectile dysfunction
. Avanafil currently has no trademarked term associated with it but it is being developed by Vivus Inc. It acts by inhibiting a specific phosphodiesterase
type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis
, as well as the retina. Other similar drugs are sildenafil
, tadalafil
and vardenafil
.
PDE5 inhibitor
A phosphodiesterase type 5 inhibitor, often shortened to PDE5 inhibitor, is a drug used to block the degradative action of phosphodiesterase type 5 on cyclic GMP in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis...
being developed for erectile dysfunction
Erectile dysfunction
Erectile dysfunction is sexual dysfunction characterized by the inability to develop or maintain an erection of the penis during sexual performance....
. Avanafil currently has no trademarked term associated with it but it is being developed by Vivus Inc. It acts by inhibiting a specific phosphodiesterase
Phosphodiesterase
A phosphodiesterase is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below...
type 5 enzyme which is found in various body tissues, but primarily in the corpus cavernosum penis
Corpus cavernosum penis
The corpus cavernosum penis is one of a pair of sponge-like regions of erectile tissue which contain most of the blood in the penis during penile erection...
, as well as the retina. Other similar drugs are sildenafil
Sildenafil
Sildenafil citrate, sold as Viagra, Revatio and under various other trade names, is a drug used to treat erectile dysfunction and pulmonary arterial hypertension . It was originally developed by British scientists and then brought to market by the US-based pharmaceutical company Pfizer...
, tadalafil
Tadalafil
Tadalafil is a PDE5 inhibitor, currently marketed in pill form for treating erectile dysfunction under the name Cialis; and under the name Adcirca for the treatment of pulmonary arterial hypertension...
and vardenafil
Vardenafil
Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction that is sold under the trade names Levitra and Staxyn.-History:...
.
Synthesis
Yamada, K.; Matsuki, K.; Omori, K.; Kikkawa, K.; 2004, .Further reading
- Faster-Working Erectile Dysfunction Drug? cbsnews.com Nov 25th 2009
- Vivus says men taking avanafil were more likely to be ready for sex within 15 minutes taragana.com business news Jan 11th 2010
- New Avanafil Works In 15 minutes Compared To Cialis And Viagra Taking 30 June 28th 2011