Asialoglycoprotein
Encyclopedia
If terminal sialic acid
residues are removed from glycoprotein
s, the resulting proteins are known as asialoglycoproteins.
The exposure of the subterminal galactose
residues results in rapid clearance of the glycoproteins from the circulation through hepatocyte
asialoglycoprotein receptors on Kuppfer cells.
Sialic acid
Sialic acid is a generic term for the N- or O-substituted derivatives of neuraminic acid, a monosaccharide with a nine-carbon backbone. It is also the name for the most common member of this group, N-acetylneuraminic acid...
residues are removed from glycoprotein
Glycoprotein
Glycoproteins are proteins that contain oligosaccharide chains covalently attached to polypeptide side-chains. The carbohydrate is attached to the protein in a cotranslational or posttranslational modification. This process is known as glycosylation. In proteins that have segments extending...
s, the resulting proteins are known as asialoglycoproteins.
The exposure of the subterminal galactose
Galactose
Galactose , sometimes abbreviated Gal, is a type of sugar that is less sweet than glucose. It is a C-4 epimer of glucose....
residues results in rapid clearance of the glycoproteins from the circulation through hepatocyte
Hepatocyte
A hepatocyte is a cell of the main tissue of the liver. Hepatocytes make up 70-80% of the liver's cytoplasmic mass.These cells are involved in:* Protein synthesis* Protein storage* Transformation of carbohydrates...
asialoglycoprotein receptors on Kuppfer cells.