Antonei Csoka
Encyclopedia
Antonei B. Csoka, Ph.D. is a biogerontologist at the Roswell Park Cancer Institute
who works on the molecular biology
of aging.
that identified the Lamin A gene as the cause of the accelerated aging disease
Hutchinson-Gilford Progeria
Syndrome. He also showed that atypical cases of Progeria can be caused by mutations in the same gene, and currently researches the molecular etiology
of these disorders. He showed that lamin A is a marker for human embryonic stem cell
differentiation, which may have application in regenerative medicine
, rejuvenation
and cloning
. In earlier work, he cloned the human hyaluronidase
gene family.
, cryonics
and transhumanism
. He is a scientific advisor to the Alcor Life Extension Foundation
, and the Lifeboat Foundation, and was featured in the first Immortality Institute film, Exploring Life Extension (2005) produced by Bruce Klein.
Roswell Park Cancer Institute
The Roswell Park Cancer Institute is a comprehensive cancer research and treatment center located in Buffalo, New York. Founded in 1898 by Dr. Roswell Park, it was the first dedicated medical facility for cancer treatment and research in the United States. The facility is involved in drug...
who works on the molecular biology
Molecular biology
Molecular biology is the branch of biology that deals with the molecular basis of biological activity. This field overlaps with other areas of biology and chemistry, particularly genetics and biochemistry...
of aging.
Research
He was a member of the consortiumConsortium
A consortium is an association of two or more individuals, companies, organizations or governments with the objective of participating in a common activity or pooling their resources for achieving a common goal....
that identified the Lamin A gene as the cause of the accelerated aging disease
Accelerated aging disease
A DNA repair-deficiency disorder is a medical condition due to reduced functionality of DNA repair.DNA repair defects are seen in nearly all of the diseases described as accelerated aging disease, in which various tissues, organs or systems of the human body age prematurely...
Hutchinson-Gilford Progeria
Progeria
Progeria is an extremely rare genetic condition wherein symptoms resembling aspects of aging are manifested at an early age. The word progeria comes from the Greek words "pro" , meaning "before", and "géras" , meaning "old age"...
Syndrome. He also showed that atypical cases of Progeria can be caused by mutations in the same gene, and currently researches the molecular etiology
Etiology
Etiology is the study of causation, or origination. The word is derived from the Greek , aitiologia, "giving a reason for" ....
of these disorders. He showed that lamin A is a marker for human embryonic stem cell
Embryonic stem cell
Embryonic stem cells are pluripotent stem cells derived from the inner cell mass of the blastocyst, an early-stage embryo. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells...
differentiation, which may have application in regenerative medicine
Regenerative medicine
Regenerative medicine is the "process of replacing or regenerating human cells, tissues or organs to restore orestablish normal function". This field holds the promise of regenerating damaged tissues and organs in the body by replacing damaged tissue and/or by stimulating the body's own repair...
, rejuvenation
Rejuvenation
Rejuvenation may refer to:*Rejuvenation , reversing the aging process*Rejuvenation , when the base level that a river is flowing down to is lowered*Rejuvenation , 1974*Rejuvenation , 2009...
and cloning
Cloning
Cloning in biology is the process of producing similar populations of genetically identical individuals that occurs in nature when organisms such as bacteria, insects or plants reproduce asexually. Cloning in biotechnology refers to processes used to create copies of DNA fragments , cells , or...
. In earlier work, he cloned the human hyaluronidase
Hyaluronidase
The hyaluronidases are a family of enzymes that degrade hyaluronic acid.In humans, there are six associated genes, including HYAL1, HYAL2, HYAL3, and PH-20/SPAM1.-Use as a drug:...
gene family.
Life extension activities
Dr. Csoka is a prominent proponent of life extensionLife extension
Life extension science, also known as anti-aging medicine, experimental gerontology, and biomedical gerontology, is the study of slowing down or reversing the processes of aging to extend both the maximum and average lifespan...
, cryonics
Cryonics
Cryonics is the low-temperature preservation of humans and animals who can no longer be sustained by contemporary medicine, with the hope that healing and resuscitation may be possible in the future. Cryopreservation of people or large animals is not reversible with current technology...
and transhumanism
Transhumanism
Transhumanism, often abbreviated as H+ or h+, is an international intellectual and cultural movement that affirms the possibility and desirability of fundamentally transforming the human condition by developing and making widely available technologies to eliminate aging and to greatly enhance human...
. He is a scientific advisor to the Alcor Life Extension Foundation
Alcor Life Extension Foundation
The Alcor Life Extension Foundation, most often referred to as Alcor, is a Scottsdale, Arizona, USA-based nonprofit company that researches, advocates for and performs cryonics, the preservation of humans in liquid nitrogen after legal death, with hopes of restoring them to full health when new...
, and the Lifeboat Foundation, and was featured in the first Immortality Institute film, Exploring Life Extension (2005) produced by Bruce Klein.
See also
- Alcor Life Extension FoundationAlcor Life Extension FoundationThe Alcor Life Extension Foundation, most often referred to as Alcor, is a Scottsdale, Arizona, USA-based nonprofit company that researches, advocates for and performs cryonics, the preservation of humans in liquid nitrogen after legal death, with hopes of restoring them to full health when new...
- CryonicsCryonicsCryonics is the low-temperature preservation of humans and animals who can no longer be sustained by contemporary medicine, with the hope that healing and resuscitation may be possible in the future. Cryopreservation of people or large animals is not reversible with current technology...
- Human enhancementHuman enhancementHuman enhancement refers to any attempt to temporarily or permanently overcome the current limitations of the human body through natural or artificial means...
- SenescenceSenescenceSenescence or biological aging is the change in the biology of an organism as it ages after its maturity. Such changes range from those affecting its cells and their function to those affecting the whole organism...