Antibe Therapeutics
Encyclopedia
Antibe Therapeutics is a Toronto-based pharmaceutical research and development company developing inflammation
-reducing drugs. The conceived mechanism of action
is to deliver a gaseous mediator, specifically hydrogen sulfide
to sites of inflammation or injury within the human body. Hydrogen sulfide enhances the resolution of injury and repair of damage. Antibe was founded by John L. Wallace
, co-founder of NicOx
, the company that was the first to commercialize gaseous mediator technology. Antibe's board of directors
includes Louis Ignarro
, awarded the 1998 Nobel Prize in Physiology or Medicine
for the basic research
that underpins gaseous mediator technology, and Dr. Daniel K. Podolsky, Presient of the University of Texas Southwestern. Antibe's products have not yet been approved by the Food and Drug Administration
. The lead drug, ATB-346, is a hydrogen sulfide-releasing derivative of naproxen, a commonly used non-steroidal anti-inflammatory drug
. Unlike naproxen, ATB-346 does not induce damage in the gastrointestinal tract.
Inflammation
Inflammation is part of the complex biological response of vascular tissues to harmful stimuli, such as pathogens, damaged cells, or irritants. Inflammation is a protective attempt by the organism to remove the injurious stimuli and to initiate the healing process...
-reducing drugs. The conceived mechanism of action
Mechanism of action
In pharmacology, the term mechanism of action refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect...
is to deliver a gaseous mediator, specifically hydrogen sulfide
Hydrogen sulfide
Hydrogen sulfide is the chemical compound with the formula . It is a colorless, very poisonous, flammable gas with the characteristic foul odor of expired eggs perceptible at concentrations as low as 0.00047 parts per million...
to sites of inflammation or injury within the human body. Hydrogen sulfide enhances the resolution of injury and repair of damage. Antibe was founded by John L. Wallace
John L. Wallace
John L. Wallace, PhD, MBA, FRSC, is a medical scientist and director of the Farncombe Institute at McMaster University. He is the 2009 recipient of the Premier's Summit Award in Innovation, Canada's largest value research award aimed at supporting the work of an individual scientist...
, co-founder of NicOx
NicOx
NicOx S.A. is a French pharmaceutical company. Its headquarters are at Sophia Antipolis...
, the company that was the first to commercialize gaseous mediator technology. Antibe's board of directors
Board of directors
A board of directors is a body of elected or appointed members who jointly oversee the activities of a company or organization. Other names include board of governors, board of managers, board of regents, board of trustees, and board of visitors...
includes Louis Ignarro
Louis Ignarro
Louis J. Ignarro is an American pharmacologist. He was corecipient of the 1998 Nobel Prize in Physiology or Medicine with Robert F...
, awarded the 1998 Nobel Prize in Physiology or Medicine
Nobel Prize in Physiology or Medicine
The Nobel Prize in Physiology or Medicine administered by the Nobel Foundation, is awarded once a year for outstanding discoveries in the field of life science and medicine. It is one of five Nobel Prizes established in 1895 by Swedish chemist Alfred Nobel, the inventor of dynamite, in his will...
for the basic research
Basic Research
Basic Research is an herbal supplement and cosmetics manufacturer based in Salt Lake City, Utah that distributes products through a large number of subsidiaries. In addition, their products are sold domestically and internationally through a number of high-end retailers. Dennis Gay is the...
that underpins gaseous mediator technology, and Dr. Daniel K. Podolsky, Presient of the University of Texas Southwestern. Antibe's products have not yet been approved by the Food and Drug Administration
Food and Drug Administration
The Food and Drug Administration is an agency of the United States Department of Health and Human Services, one of the United States federal executive departments...
. The lead drug, ATB-346, is a hydrogen sulfide-releasing derivative of naproxen, a commonly used non-steroidal anti-inflammatory drug
Non-steroidal anti-inflammatory drug
Nonsteroidal anti-inflammatory drugs, usually abbreviated to NSAIDs or NAIDs, but also referred to as nonsteroidal anti-inflammatory agents/analgesics or nonsteroidal Anti-inflammatory medicines , are drugs with analgesic and antipyretic effects and which have, in higher doses, anti-inflammatory...
. Unlike naproxen, ATB-346 does not induce damage in the gastrointestinal tract.