Angiomotin is a 675-residue protein that increases the random migration of endothelial cells as well as the migration of endothelial cells toward growth factors.

In the presence of angiostatin

Angiostatin

Angiostatin is a naturally occurring protein found in several animal species, including humans. It is an endogenous angiogenesis inhibitor , and it is currently undergoing clinical trials for its use in anticancer therapy.-Structure:Angiostatin is a 38 kDa fragment of a larger protein, plasmin ...

, endothelial cells that overexpress angiomotin exhibit a significant reduction in migration toward growth factors as well as an inability to form tubule

Tubule

A tubule is a very small tube or fistular structure.A system of surface-connected membranes in muscle that enables a nerve impulse to travel to the interior of the muscle fibre.In anatomy, a tubule is a minute tube lined with glandular epithelium....

s in vitro

In vitro

In vitro refers to studies in experimental biology that are conducted using components of an organism that have been isolated from their usual biological context in order to permit a more detailed or more convenient analysis than can be done with whole organisms. Colloquially, these experiments...

. These observations are consistent with the localization of angiomotin in the leading edge of migrating cells. Angiostatin, therefore, disrupts the normal migratory function of Angiomotin.