Angiolathyrism
Encyclopedia
Angio = Blood vessel, Lathyrism = disease due to Lathyrus Sativus
. It is commonly associated with Osteolathyrism
and Neurolathyrism and is caused by over consumption of Lathyrus sativus
, also known as sweet pea. Main chemical responsible is β-Aminopropionitrile
which prevents collagen cross-linking thus making the blood vessel, especially the Tunica media
, weak. This can result in Cystic medial necrosis or a picture similar to Marfan syndrome
. The damaged vessels are at an increased risk of Dissection
.
Lathyrus sativus
Lathyrus sativus, is a legume commonly grown for human consumption and livestock feed in Asia and East Africa. It is a particularly important crop in areas that are prone to drought and famine, and is thought of as an 'insurance crop' as it produces reliable yields when all other crops...
. It is commonly associated with Osteolathyrism
Osteolathyrism
Osteolathyrism is a collagen cross-linking deficiency brought on by dietary over-reliance on the seeds of Lathyrus sativus. It is commonly seen in combination with neurolathyrism and angiolathyrism in impoverished areas where famine demands reliance on a crop with known detrimental effects...
and Neurolathyrism and is caused by over consumption of Lathyrus sativus
Lathyrus sativus
Lathyrus sativus, is a legume commonly grown for human consumption and livestock feed in Asia and East Africa. It is a particularly important crop in areas that are prone to drought and famine, and is thought of as an 'insurance crop' as it produces reliable yields when all other crops...
, also known as sweet pea. Main chemical responsible is β-Aminopropionitrile
Aminopropionitrile
Aminopropionitrile is a nitrile. It is an antirheumatic agent in veterinary medicine. It can cause osteolathyrism.- Synthesis :Aminopropionitrile can be prepared by the reaction of ammonium hydroxide with acrylonitrile....
which prevents collagen cross-linking thus making the blood vessel, especially the Tunica media
Tunica media
The tunica media is the middle layer of an artery or vein.-Artery:It is made up of smooth muscle cells and elastic tissue...
, weak. This can result in Cystic medial necrosis or a picture similar to Marfan syndrome
Marfan syndrome
Marfan syndrome is a genetic disorder of the connective tissue. People with Marfan's tend to be unusually tall, with long limbs and long, thin fingers....
. The damaged vessels are at an increased risk of Dissection
Dissection (medical)
In medical pathology, dissection refers to a tear within the wall of a blood vessel, which allows blood to separate the wall layers, creating a pseudoaneurysm.- Types :Examples include:*Aortic dissection...
.