Alveolar rhabdomyosarcoma
Encyclopedia
Alveolar rhabdomyosarcoma is a type of rhabdomyosarcoma
characterized by its appearance, which is similar to the alveoli of the lungs.
It can be associated with a fusion protein between PAX3
and FKHR (now known as FOXO1
).
It can also be associated with PAX7
-FKHR.
Rhabdomyosarcoma
A rhabdomyosarcoma is a type of cancer, specifically a sarcoma , in which the cancer cells are thought to arise from skeletal muscle progenitors. It can also be found attached to muscle tissue, wrapped around intestines, or in any anatomic location...
characterized by its appearance, which is similar to the alveoli of the lungs.
It can be associated with a fusion protein between PAX3
PAX3
PAX3 is a gene that belongs to the paired box family of transcription factors. This gene was formerly known as splotch. PAX3 has been identified with ear, eye and facial development. Mutations in it can cause Waardenburg syndrome types 1 and 3...
and FKHR (now known as FOXO1
FOXO1
Forkhead box protein O1 also known as forkhead in rhabdomyosarcoma is a protein that in humans is encoded by the FOXO1 gene.- Function :...
).
It can also be associated with PAX7
PAX7
Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene.- Function :Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1....
-FKHR.