Aleglitazar
Encyclopedia
Aleglitazar is a peroxisome proliferator-activated receptor
agonist
(hence a PPAR modulator
) with affinity to PPARα and PPARγ, which is being developed by Hoffmann–La Roche for the treatment of type II diabetes
. It is currently in phase II clinical trials.
Peroxisome proliferator-activated receptor
In the field of molecular biology, the peroxisome proliferator-activated receptors are a group of nuclear receptor proteins that function as transcription factors regulating the expression of genes...
agonist
Agonist
An agonist is a chemical that binds to a receptor of a cell and triggers a response by that cell. Agonists often mimic the action of a naturally occurring substance...
(hence a PPAR modulator
PPAR modulator
PPAR modulators are drugs which act upon the peroxisome proliferator-activated receptor.-Classification:PPARα and PPARγ are the molecular targets of a number of marketed drugs...
) with affinity to PPARα and PPARγ, which is being developed by Hoffmann–La Roche for the treatment of type II diabetes
Diabetes mellitus type 2
Diabetes mellitus type 2formerly non-insulin-dependent diabetes mellitus or adult-onset diabetesis a metabolic disorder that is characterized by high blood glucose in the context of insulin resistance and relative insulin deficiency. Diabetes is often initially managed by increasing exercise and...
. It is currently in phase II clinical trials.