Albert L. Lehninger
Encyclopedia
Albert Lester Lehninger (February 17, 1917 – March 4, 1986) was an American
biochemist
in the field of bioenergetics
. He made fundamental contributions to the current understanding of metabolism
at a molecular level. In 1948, he discovered, with Eugene P. Kennedy, that mitochondria are the site of oxidative phosphorylation
in eukaryotes, which ushered in the modern study of energy transduction. He is the author of a number of classic texts, including: Biochemistry, The Mitochondrion, Bioenergetics and, most notably, his series Principles of Biochemistry. The latter is a widely used text for introductory biochemistry courses at the college and university levels.
, Connecticut
, U.S
. He earned his Bachelor of Arts in English from Wesleyan University
(1939) and went on to pursue both his Masters of Science (1940) and Ph.D. (1942) at the University of Wisconsin–Madison
. His doctoral research involved the metabolism of acetoacetate and fatty acid oxidation
by liver cells.
and the University of Chicago
. In 1952, he went to the Johns Hopkins University
School of Medicine assuming the title of DeLamar Professor of the Department of Biological Chemistry. He served in this position until 1978, when he was appointed to the role of University Professor of Medical Sciences. He held this title until his death in 1986.
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
biochemist
Biochemist
Biochemists are scientists who are trained in biochemistry. Typical biochemists study chemical processes and chemical transformations in living organisms. The prefix of "bio" in "biochemist" can be understood as a fusion of "biological chemist."-Role:...
in the field of bioenergetics
Biological thermodynamics
Biological thermodynamics is a phrase that is sometimes used to refer to bioenergetics, the study of energy transformation in the biological sciences...
. He made fundamental contributions to the current understanding of metabolism
Metabolism
Metabolism is the set of chemical reactions that happen in the cells of living organisms to sustain life. These processes allow organisms to grow and reproduce, maintain their structures, and respond to their environments. Metabolism is usually divided into two categories...
at a molecular level. In 1948, he discovered, with Eugene P. Kennedy, that mitochondria are the site of oxidative phosphorylation
Oxidative phosphorylation
Oxidative phosphorylation is a metabolic pathway that uses energy released by the oxidation of nutrients to produce adenosine triphosphate . Although the many forms of life on earth use a range of different nutrients, almost all aerobic organisms carry out oxidative phosphorylation to produce ATP,...
in eukaryotes, which ushered in the modern study of energy transduction. He is the author of a number of classic texts, including: Biochemistry, The Mitochondrion, Bioenergetics and, most notably, his series Principles of Biochemistry. The latter is a widely used text for introductory biochemistry courses at the college and university levels.
Early life and education
Lehninger was born in BridgeportBridgeport, Connecticut
Bridgeport is the most populous city in the U.S. state of Connecticut. Located in Fairfield County, the city had an estimated population of 144,229 at the 2010 United States Census and is the core of the Greater Bridgeport area...
, Connecticut
Connecticut
Connecticut is a state in the New England region of the northeastern United States. It is bordered by Rhode Island to the east, Massachusetts to the north, and the state of New York to the west and the south .Connecticut is named for the Connecticut River, the major U.S. river that approximately...
, U.S
United States
The United States of America is a federal constitutional republic comprising fifty states and a federal district...
. He earned his Bachelor of Arts in English from Wesleyan University
Wesleyan University
Wesleyan University is a private liberal arts college founded in 1831 and located in Middletown, Connecticut. According to the Carnegie Foundation for the Advancement of Teaching, Wesleyan is the only Baccalaureate College in the nation that emphasizes undergraduate instruction in the arts and...
(1939) and went on to pursue both his Masters of Science (1940) and Ph.D. (1942) at the University of Wisconsin–Madison
University of Wisconsin–Madison
The University of Wisconsin–Madison is a public research university located in Madison, Wisconsin, United States. Founded in 1848, UW–Madison is the flagship campus of the University of Wisconsin System. It became a land-grant institution in 1866...
. His doctoral research involved the metabolism of acetoacetate and fatty acid oxidation
Fatty acid metabolism
Fatty acids are an important source of energy and adenosine triphosphate for many cellular organisms. Excess fatty acids, glucose, and other nutrients can be stored efficiently as fat. Triglycerides yield more than twice as much energy for the same mass as do carbohydrates or proteins. All cell...
by liver cells.
Academic career
After earning his doctorate in biochemistry, Lehninger held various faculty positions at the University of Wisconsin–MadisonUniversity of Wisconsin–Madison
The University of Wisconsin–Madison is a public research university located in Madison, Wisconsin, United States. Founded in 1848, UW–Madison is the flagship campus of the University of Wisconsin System. It became a land-grant institution in 1866...
and the University of Chicago
University of Chicago
The University of Chicago is a private research university in Chicago, Illinois, USA. It was founded by the American Baptist Education Society with a donation from oil magnate and philanthropist John D. Rockefeller and incorporated in 1890...
. In 1952, he went to the Johns Hopkins University
Johns Hopkins University
The Johns Hopkins University, commonly referred to as Johns Hopkins, JHU, or simply Hopkins, is a private research university based in Baltimore, Maryland, United States...
School of Medicine assuming the title of DeLamar Professor of the Department of Biological Chemistry. He served in this position until 1978, when he was appointed to the role of University Professor of Medical Sciences. He held this title until his death in 1986.
Honors and awards
- 1948 - Paul-Lewis Award in Enzyme Chemistry
- 1951 - Guggenheim Fellowship
- 1956 - Elected to the National Academy of SciencesUnited States National Academy of SciencesThe National Academy of Sciences is a corporation in the United States whose members serve pro bono as "advisers to the nation on science, engineering, and medicine." As a national academy, new members of the organization are elected annually by current members, based on their distinguished and...
- 1969 - Remsen Award of the American Chemical SocietyAmerican Chemical SocietyThe American Chemical Society is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 161,000 members at all degree-levels and in all fields of chemistry, chemical...
- 1986 - Passano Foundation Award