Adrenosterone
Encyclopedia
Adrenosterone is a steroid hormone
with weak androgenic effect. It was first isolated in 1936 from the adrenal cortex
by Tadeus Reichstein
at the Pharmaceutical Institute in the University of Basel
. Originally, adrenosterone was called Reichstein's substance G. Adrenosterone occurs in trace amounts in humans as well as most mammals and in larger amounts in fish, where it is a precursor to the primary androgen, 11-ketotestosterone
.
Adrenosterone has shown to be converted into 11-ketotestosterone
by the Scenedesmus
algae. It is thought that a similar metabolism pathway occurs in humans, which contributes to adrenosterone's androgenic effects.
Adrenosterone is sold as a dietary supplement since 2007 under the trade name 11-OXO as a fat loss and muscle gaining supplement. It is thought to be a competitive selective 11βHSD1 inhibitor, which is responsible for activation of cortisol
from cortisone
.
11-Keto-androstenedione or 11-keto-androstenetrione are also trade names for this hormone, while the correct name would be androst-4-ene-3,11,17-trione.
Steroid hormone
A steroid hormone is a steroid that acts as a hormone. Steroid hormones can be grouped into five groups by the receptors to which they bind: glucocorticoids, mineralocorticoids, androgens, estrogens, and progestogens...
with weak androgenic effect. It was first isolated in 1936 from the adrenal cortex
Adrenal cortex
Situated along the perimeter of the adrenal gland, the adrenal cortex mediates the stress response through the production of mineralocorticoids and glucocorticoids, including aldosterone and cortisol respectively. It is also a secondary site of androgen synthesis.-Layers:Notably, the reticularis in...
by Tadeus Reichstein
Tadeus Reichstein
Tadeusz Reichstein was a Polish-born Swiss chemist and Nobel laureate.Reichstein was born into a Jewish family at Włocławek, Congress Poland, and spent his early childhood at Kiev, where his father was an engineer...
at the Pharmaceutical Institute in the University of Basel
Basel
Basel or Basle In the national languages of Switzerland the city is also known as Bâle , Basilea and Basilea is Switzerland's third most populous city with about 166,000 inhabitants. Located where the Swiss, French and German borders meet, Basel also has suburbs in France and Germany...
. Originally, adrenosterone was called Reichstein's substance G. Adrenosterone occurs in trace amounts in humans as well as most mammals and in larger amounts in fish, where it is a precursor to the primary androgen, 11-ketotestosterone
11-Ketotestosterone
11-Ketotestosterone is an oxidized form of testosterone that contains a keto group at position-11. It is related to adrenosterone, an androgen found in trace quantities in humans. In fish, 11-ketotestosterone functions as the endogenous androgenic sex hormone....
.
Adrenosterone has shown to be converted into 11-ketotestosterone
11-Ketotestosterone
11-Ketotestosterone is an oxidized form of testosterone that contains a keto group at position-11. It is related to adrenosterone, an androgen found in trace quantities in humans. In fish, 11-ketotestosterone functions as the endogenous androgenic sex hormone....
by the Scenedesmus
Scenedesmus
Scenedesmus is a genus of algae, specifically of the Chlorophyceae. They are colonial and non-motile....
algae. It is thought that a similar metabolism pathway occurs in humans, which contributes to adrenosterone's androgenic effects.
Adrenosterone is sold as a dietary supplement since 2007 under the trade name 11-OXO as a fat loss and muscle gaining supplement. It is thought to be a competitive selective 11βHSD1 inhibitor, which is responsible for activation of cortisol
Cortisol
Cortisol is a steroid hormone, more specifically a glucocorticoid, produced by the adrenal gland. It is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat,...
from cortisone
Cortisone
Cortisone is a steroid hormone. It is one of the main hormones released by the adrenal gland in response to stress. In chemical structure, it is a corticosteroid closely related to corticosterone. It is used to treat a variety of ailments and can be administered intravenously, orally,...
.
11-Keto-androstenedione or 11-keto-androstenetrione are also trade names for this hormone, while the correct name would be androst-4-ene-3,11,17-trione.